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Tbio
SRRT
Serrate RNA effector molecule homolog

Protein Summary
Description
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611405
  • ENSP00000480421
  • ENSG00000087087
  • ENST00000614484
  • ENSP00000481173
  • ENST00000618262
  • ENSP00000478341
  • ENST00000618411
  • ENSP00000483556

Symbol
  • ARS2
  • ASR2
  • ARS2
  • ASR2
  • serrate
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.94
transcription factor binding site profile
0.92
virus perturbation
0.92
ligand (protein) perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.69   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.69   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (369)
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.999989372
p_ni:  0.000010628
Score:  0.713
Data Source:  BioPlex,STRINGDB
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999858041
p_ni:  0.000141959
Score:  0.662
Data Source:  BioPlex,STRINGDB
SOST
Tclin
Novelty:  0.0009273
p_int:  0.999561049
p_ni:  0.000438951
Data Source:  BioPlex
CPSF2
Tbio
Novelty:  0.0510853
p_int:  0.998038848
p_ni:  0.001961152
Score:  0.934
Data Source:  BioPlex,STRINGDB
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.980198827
p_ni:  0.019801173
Score:  0.248
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.951611464
p_ni:  0.048388536
Score:  0.503
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.943592534
p_ni:  0.056407466
Score:  0.916
Data Source:  BioPlex,STRINGDB
RGS13
Tbio
Novelty:  0.11219302
p_int:  0.914596815
p_ni:  0.085403184
Score:  0.221
Data Source:  BioPlex,STRINGDB
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.903994547
p_ni:  0.096005453
Score:  0.552
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.776536013
p_ni:  0.223463987
Score:  0.93
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
96.5
hair color
1
3
0
1.1
93.5
heart rate response to recovery post exercise
5
2
5
81.2
alkaline phosphatase measurement
2
2
1
6.8
75.7
total cholesterol measurement
2
3
3
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
96.5
hair color
0
1.1
93.5
heart rate response to recovery post exercise
5
81.2
alkaline phosphatase measurement
1
6.8
75.7
total cholesterol measurement
3
68.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
serrate, RNA effector molecule
713235
Mouse
MGI:1933527
83701
Dog
serrate, RNA effector molecule
VGNC:46815
479731
Horse
serrate, RNA effector molecule
VGNC:23597
100067574
Cow
serrate, RNA effector molecule
VGNC:35296
527938
Species
Name
OMA
EggNOG
Inparanoid
Macaque
serrate, RNA effector molecule
Mouse
Dog
serrate, RNA effector molecule
Horse
serrate, RNA effector molecule
Cow
serrate, RNA effector molecule
Publication Statistics
PubMed Score 213.69
PubMed score by year
PubTator Score 43.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title