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Tbio
SRRM2
Serine/arginine repetitive matrix protein 2

Protein Summary
Description
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301740
  • ENSP00000301740
  • ENSG00000167978
  • ENST00000630499
  • ENSP00000487247

Symbol
  • KIAA0324
  • SRL300
  • SRM300
  • CWF21
  • Cwc21
  • 300-KD
  • SRL300
  • SRm300
  • HSPC075
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
hub protein
1
interacting protein
1
transcription factor binding site profile
0.89
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (312)
MDK
Tchem
Novelty:  0.00145301
p_int:  0.997421492
p_ni:  0.002578508
Score:  0.226
Data Source:  BioPlex,STRINGDB
EPB41L2
Tbio
Novelty:  0.0311733
p_int:  0.98955379
p_ni:  0.010446209
Data Source:  BioPlex
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.989128474
p_ni:  0.010871526
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.982120356
p_ni:  0.017879644
Data Source:  BioPlex
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.977202304
p_ni:  0.022797696
Score:  0.211
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.970313942
p_ni:  0.029686058
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.969098817
p_ni:  0.030901183
Data Source:  BioPlex
RSBN1L
Tdark
Novelty:  5.23364486
p_int:  0.956166587
p_ni:  0.043833413
Score:  0.671
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.952393492
p_ni:  0.047606508
Score:  0.501
Data Source:  BioPlex,STRINGDB
AKAP17A
Tbio
Family:  Enzyme
Novelty:  0.02860381
p_int:  0.942825474
p_ni:  0.057174526
Score:  0.621
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
93.4
eosinophil percentage of leukocytes
2
2
2
87.5
intraocular pressure measurement
1
1
0
8.7
70.2
body height
1
1
1
65.5
eosinophil percentage of granulocytes
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.4
eosinophil percentage of leukocytes
2
87.5
intraocular pressure measurement
0
8.7
70.2
body height
1
65.5
eosinophil percentage of granulocytes
1
59.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/arginine repetitive matrix 2
VGNC:5923
453842
Macaque
serine/arginine repetitive matrix 2
698477
Mouse
MGI:1923206
75956
Rat
RGD:1310163
302969
Dog
serine/arginine repetitive matrix 2
VGNC:54071
609646
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/arginine repetitive matrix 2
Macaque
serine/arginine repetitive matrix 2
Mouse
Rat
Dog
serine/arginine repetitive matrix 2
Publication Statistics
PubMed Score 27.56
PubMed score by year
PubTator Score 12.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title