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Tbio
SRPRB
Signal recognition particle receptor subunit beta

Protein Summary
Description
Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000466490
  • ENSP00000418401
  • ENSG00000144867

Symbol
  • APMCF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.99
interacting protein
0.97
biological process
0.76
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.48   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.48   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (225)
SRPRA
Tchem
Novelty:  0.01248718
p_int:  0.999998295
p_ni:  0.000001705
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.999967282
p_ni:  0.000032717
p_wrong:  1e-9
Score:  0.533
Data Source:  BioPlex,STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
p_int:  0.996649295
p_ni:  0.003350685
p_wrong:  2e-8
Data Source:  BioPlex
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.995100943
p_ni:  0.004899057
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.994494873
p_ni:  0.005505126
Data Source:  BioPlex
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.994062852
p_ni:  0.005937148
Score:  0.638
Data Source:  BioPlex,STRINGDB
EMB
Tbio
Novelty:  0.00135577
p_int:  0.9926554
p_ni:  0.001599495
p_wrong:  0.005745105
Data Source:  BioPlex
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.991724483
p_ni:  0.008275517
Score:  0.216
Data Source:  BioPlex,STRINGDB
HMOX1
Tchem
Family:  Enzyme
Novelty:  0.00013981
p_int:  0.990219626
p_ni:  0.009780374
Data Source:  BioPlex
DHRS7
Tbio
Family:  Enzyme
Novelty:  0.16713756
p_int:  0.986736747
p_ni:  0.013263253
Score:  0.162
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Unfolded Protein Response (UPR)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
iron biomarker measurement
7
6
7
13.5
99.5
transferrin measurement
2
3
4
98.2
transferrin saturation measurement
3
4
5
98
mean corpuscular hemoglobin concentration
5
5
6
97.9
alcohol drinking
1
3
3
93.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
iron biomarker measurement
7
13.5
99.5
transferrin measurement
4
98.2
transferrin saturation measurement
5
98
mean corpuscular hemoglobin concentration
6
97.9
alcohol drinking
3
93.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRP receptor subunit beta
VGNC:7126
100610929
Macaque
SRP receptor beta subunit
719024
Mouse
MGI:102964
20818
Cow
SRP receptor subunit beta
VGNC:35291
100138613
Pig
SRP receptor beta subunit
100523141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRP receptor subunit beta
Macaque
SRP receptor beta subunit
Mouse
Cow
SRP receptor subunit beta
Pig
SRP receptor beta subunit
Publication Statistics
PubMed Score 25.48
PubMed score by year
PubTator Score 5.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title