Protein Summary
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reduci ...more
- ENST00000357311
- ENSP00000349863
- ENSG00000135250
- ENST00000393651
- ENSP00000377262
- ENST00000489828
- ENSP00000419791
- SFRSK2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
molecular function | 0.98 | ||
transcription factor perturbation | 0.88 | ||
kinase perturbation | 0.84 | ||
transcription factor | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.11 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.11 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (213)
U2AF1
Novelty: 0.01181981
p_int: 0.999632666
p_ni: 0.000367334
Score: 0.588
Data Source: BioPlex,STRINGDB
U2AF2
Novelty: 0.00590935
p_int: 0.998950517
p_ni: 0.001049483
Score: 0.789
Data Source: BioPlex,STRINGDB
LUC7L
Novelty: 0.05748021
p_int: 0.995332907
p_ni: 0.004667093
Score: 0.704
Data Source: BioPlex,STRINGDB
LUC7L2
Novelty: 0.36989457
p_int: 0.980365462
p_ni: 0.019634538
Score: 0.221
Data Source: BioPlex,STRINGDB
SNRNP70
Novelty: 0.00116631
p_int: 0.812684533
p_ni: 0.187315467
Score: 0.8
Data Source: BioPlex,STRINGDB
ZRSR2
Novelty: 0.03449891
p_int: 0.762414726
p_ni: 0.237585274
Score: 0.53
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
WikiPathways | mRNA Processing | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
mRNA Processing | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (5)
Components (5)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
waist-hip ratio | 2 | 2 | 2 | 80.6 | |||||
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 76.2 | |||||
7 | 5 | 1 | 1.1 | 74 | |||||
self reported educational attainment | 2 | 2 | 2 | 74 | |||||
biological sex | 1 | 1 | 1 | 69.4 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
waist-hip ratio | 2 | 80.6 | |||||
BMI-adjusted waist-hip ratio | 2 | 76.2 | |||||
1 | 1.1 | 74 | |||||
self reported educational attainment | 2 | 74 | |||||
biological sex | 1 | 69.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | SRSF protein kinase 2 | VGNC:4516 | 463641 | |||||
Macaque | SRSF protein kinase 2 | 697351 | ||||||
Mouse | MGI:1201408 | 20817 | ||||||
Rat | RGD:1305107 | 296753 | ||||||
Dog | SRSF protein kinase 2 | VGNC:46811 | 475894 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | SRSF protein kinase 2 | |||||
Macaque | SRSF protein kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SRSF protein kinase 2 | |||||
Publication Statistics
PubMed Score 30.11
PubMed score by year
PubTator Score 20.39
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (42)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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