Tchem SRPK2 SRSF protein kinase 2

Protein Summary

Description

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Uniprot Accession IDs

• P78362
• A8MVX2
• O75220
• O75221
• Q6NUL0
• Q6V1X2
• Q8IYQ3

Gene Name

• SRPK2

Ensembl ID

• ENST00000357311
• ENSP00000349863
• ENSG00000135250
• ENST00000393651
• ENSP00000377262
• ENST00000489828
• ENSP00000419791

Symbol

• SFRSK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
molecular function	0.98
transcription factor perturbation	0.88
kinase perturbation	0.84
transcription factor	0.84

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Srsf Protein Kinase 2

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Srpk Family / Srsf Protein Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.9   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.9   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0