Tchem SRPK2 SRSF protein kinase 2

Protein Summary

Description

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Uniprot Accession IDs

• P78362
• A8MVX2
• O75220
• O75221
• Q6NUL0
• Q6V1X2
• Q8IYQ3

Gene Name

• SRPK2

Ensembl ID

• ENST00000357311
• ENSP00000349863
• ENSG00000135250
• ENST00000393651
• ENSP00000377262
• ENST00000489828
• ENSP00000419791

Symbol

• SFRSK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
molecular function	0.98
transcription factor perturbation	0.88
kinase perturbation	0.84
transcription factor	0.84

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Srsf Protein Kinase 2

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Srpk Family / Srsf Protein Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.11   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.11   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (5)

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

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1 – 1 of 1

KW-2449

SRPK2Tchem Kinase

pKd : 8.52

Protein-Protein Interactions (213)

Explore Interacting Targets

1 – 10 of 213

• See Interactions on String-DB

U2AF1

Tbio

Novelty:  0.01181981

p_int:  0.999632666

p_ni:  0.000367334

Score:  0.588

Data Source:  BioPlex,STRINGDB

U2AF2

Tbio

Novelty:  0.00590935

p_int:  0.998950517

p_ni:  0.001049483

Score:  0.789

Data Source:  BioPlex,STRINGDB

LUC7L

Tbio

Novelty:  0.05748021

p_int:  0.995332907

p_ni:  0.004667093

Score:  0.704

Data Source:  BioPlex,STRINGDB

LUC7L2

Tdark

Novelty:  0.36989457

p_int:  0.980365462

p_ni:  0.019634538

Score:  0.221

Data Source:  BioPlex,STRINGDB

PUF60

Tbio

Novelty:  0.02667356

p_int:  0.949860248

p_ni:  0.050139752

Data Source:  BioPlex

SNRNP70

Tbio

Novelty:  0.00116631

p_int:  0.812684533

p_ni:  0.187315467

Score:  0.8

Data Source:  BioPlex,STRINGDB

ZRSR2

Tbio

Novelty:  0.03449891

p_int:  0.762414726

p_ni:  0.237585274

Score:  0.53

Data Source:  BioPlex,STRINGDB

DDX23

Tbio

Family:  Enzyme

Novelty:  0.03592096

Score:  0.942

Data Source:  STRINGDB

SRSF1

Tbio

Novelty:  0.00074446

Score:  0.936

Data Source:  STRINGDB

SRSF2

Tbio

Novelty:  0.00207072

Score:  0.853

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

WikiPathways (1)

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Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	mRNA Processing	134 targets	WP411_r105857

Name	Explore in Pharos	Explore in Source
mRNA Processing	134 targets	WP411_r105857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (5)

Components (5)

Processes (17)

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GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
protein serine/threonine kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
14-3-3 protein binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	2	2	2		80.6
BMI-adjusted waist-hip ratio	EFO_0007788	2	2	2		76.2
schizophrenia	EFO_0000692	7	5	1	1.1	74
self reported educational attainment	EFO_0004784	2	2	2		74
biological sex	PATO_0000047	1	1	1		69.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	2		80.6
BMI-adjusted waist-hip ratio	EFO_0007788	2		76.2
schizophrenia	EFO_0000692	1	1.1	74
self reported educational attainment	EFO_0004784	2		74
biological sex	PATO_0000047	1		69.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Differentiation
Kinase
mRNA processing
mRNA splicing
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
age-related macular degeneration
anorexia nervosa
atrophic macular degeneration
autism spectrum disorder
biological sex
bipolar disorder
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
cognitive function measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SRSF protein kinase 2	VGNC:4516	463641
Macaque	SRSF protein kinase 2		697351
Mouse	serine/arginine-rich protein specific kinase 2	MGI:1201408	20817
Rat	SRSF protein kinase 2	RGD:1305107	296753
Dog	SRSF protein kinase 2	VGNC:46811	475894

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SRSF protein kinase 2
Macaque	SRSF protein kinase 2
Mouse	serine/arginine-rich protein specific kinase 2
Rat	SRSF protein kinase 2
Dog	SRSF protein kinase 2

Publication Statistics

PubMed Score 30.11

PubMed score by year

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PubTator Score 20.39

PubTator score by year

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Patents

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Related Publications

Text Mined References (42)

GeneRif Annotations (17)

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PMID	Year	Title