Protein Summary
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in wh ...more
- ENST00000373825
- ENSP00000362931
- ENSG00000096063
- ENST00000423325
- ENSP00000391069
- SFRSK1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.97 | ||
kinase perturbation | 0.95 | ||
disease perturbation | 0.93 | ||
virus perturbation | 0.85 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.41 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 422 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.41 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 422 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (127)
RBM27
Novelty: 0.04875536
p_int: 0.999602517
p_ni: 0.000397482
p_wrong: 1e-9
Score: 0.444
Data Source: BioPlex,STRINGDB
U2AF2
Novelty: 0.00590935
p_int: 0.999531098
p_ni: 0.000468902
Score: 0.871
Data Source: BioPlex,STRINGDB
U2AF1
Novelty: 0.01181981
p_int: 0.999138306
p_ni: 0.000861694
Score: 0.677
Data Source: BioPlex,STRINGDB
DROSHA
Family: Enzyme
Novelty: 0.00107123
p_int: 0.995696048
p_ni: 0.004303952
Score: 0.826
Data Source: BioPlex,STRINGDB
LUC7L
Novelty: 0.05748021
p_int: 0.994128586
p_ni: 0.005871414
Score: 0.703
Data Source: BioPlex,STRINGDB
DHX8
Family: Enzyme
Novelty: 0.01584745
p_int: 0.993422473
p_ni: 0.006577527
Score: 0.243
Data Source: BioPlex,STRINGDB
ACIN1
Novelty: 0.01675479
p_int: 0.993414357
p_ni: 0.006585643
Score: 0.734
Data Source: BioPlex,STRINGDB
HDGFL2
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.981127986
p_ni: 0.018872013
Data Source: BioPlex
ZRSR2
Novelty: 0.03449891
p_int: 0.974167449
p_ni: 0.025832551
Score: 0.246
Data Source: BioPlex,STRINGDB
RBMX2
Novelty: 0.08867468
p_int: 0.911907614
p_ni: 0.088092366
p_wrong: 2.1e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
KEGG (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Herpes simplex virus 1 infection | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Herpes simplex virus 1 infection | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (5)
Components (6)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 1 | 2 | 68.8 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 63.4 | |||||
eosinophil count | 1 | 1 | 1 | 60.2 | |||||
waist-hip ratio | 1 | 1 | 1 | 45.7 | |||||
reticulocyte count | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 68.8 | |||||
mean reticulocyte volume | 1 | 63.4 | |||||
eosinophil count | 1 | 60.2 | |||||
waist-hip ratio | 1 | 45.7 | |||||
reticulocyte count | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | SRSF protein kinase 1 | VGNC:3711 | 462640 | |||||
Macaque | SRSF protein kinase 1 | 719039 | ||||||
Mouse | MGI:106908 | 20815 | ||||||
Rat | RGD:1308272 | 361811 | ||||||
Dog | SRSF protein kinase 1 | VGNC:54365 | 474887 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | SRSF protein kinase 1 | |||||
Macaque | SRSF protein kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SRSF protein kinase 1 | |||||
Publication Statistics
PubMed Score 123.41
PubMed score by year
PubTator Score 84.89
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (86)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
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