You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SRPK1
SRSF protein kinase 1

Protein Summary
Description
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in wh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373825
  • ENSP00000362931
  • ENSG00000096063
  • ENST00000423325
  • ENSP00000391069

Symbol
  • SFRSK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
kinase perturbation
0.95
disease perturbation
0.93
virus perturbation
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.41   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 422   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.41   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 422   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (127)
RBM27
Tdark
Novelty:  0.04875536
p_int:  0.999602517
p_ni:  0.000397482
p_wrong:  1e-9
Score:  0.444
Data Source:  BioPlex,STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
p_int:  0.999531098
p_ni:  0.000468902
Score:  0.871
Data Source:  BioPlex,STRINGDB
U2AF1
Tbio
Novelty:  0.01181981
p_int:  0.999138306
p_ni:  0.000861694
Score:  0.677
Data Source:  BioPlex,STRINGDB
DROSHA
Tbio
Family:  Enzyme
Novelty:  0.00107123
p_int:  0.995696048
p_ni:  0.004303952
Score:  0.826
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.994128586
p_ni:  0.005871414
Score:  0.703
Data Source:  BioPlex,STRINGDB
DHX8
Tbio
Family:  Enzyme
Novelty:  0.01584745
p_int:  0.993422473
p_ni:  0.006577527
Score:  0.243
Data Source:  BioPlex,STRINGDB
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.993414357
p_ni:  0.006585643
Score:  0.734
Data Source:  BioPlex,STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.981127986
p_ni:  0.018872013
Data Source:  BioPlex
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.974167449
p_ni:  0.025832551
Score:  0.246
Data Source:  BioPlex,STRINGDB
RBMX2
Tbio
Novelty:  0.08867468
p_int:  0.911907614
p_ni:  0.088092366
p_wrong:  2.1e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
68.8
mean reticulocyte volume
1
1
1
63.4
eosinophil count
1
1
1
60.2
waist-hip ratio
1
1
1
45.7
reticulocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
68.8
mean reticulocyte volume
1
63.4
eosinophil count
1
60.2
waist-hip ratio
1
45.7
reticulocyte count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRSF protein kinase 1
VGNC:3711
462640
Macaque
SRSF protein kinase 1
719039
Mouse
MGI:106908
20815
Rat
RGD:1308272
361811
Dog
SRSF protein kinase 1
VGNC:54365
474887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRSF protein kinase 1
Macaque
SRSF protein kinase 1
Mouse
Rat
Dog
SRSF protein kinase 1
Publication Statistics
PubMed Score 123.41
PubMed score by year
PubTator Score 84.89
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title