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Tbio
SRP72
Signal recognition particle subunit SRP72

Protein Summary
Description
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript varia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342756
  • ENSP00000342181
  • ENSG00000174780
  • ENST00000510663
  • ENSP00000424576
  • ENST00000642900
  • ENSP00000495128

Symbol
  • BMFF
  • BMFS1
  • HEL103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
drug perturbation
0.99
interacting protein
0.99
disease perturbation
0.93
transcription factor perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.46   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.46   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
SRP68
Tbio
Novelty:  0.04666697
p_int:  0.999987647
p_ni:  0.000012353
Score:  0.999
Data Source:  BioPlex,STRINGDB
SRP9
Tbio
Novelty:  0.02243103
p_int:  0.999976389
p_ni:  0.000023611
Score:  0.999
Data Source:  BioPlex,STRINGDB
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.788741447
p_ni:  0.211258553
Score:  0.181
Data Source:  BioPlex,STRINGDB
SRP19
Tbio
Novelty:  0.01831843
Score:  0.999
Data Source:  STRINGDB
SRP14
Tbio
Novelty:  0.03745351
Score:  0.999
Data Source:  STRINGDB
SRP54
Tbio
Novelty:  0.00535567
Score:  0.999
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
SRPRA
Tchem
Novelty:  0.01248718
Score:  0.98
Data Source:  STRINGDB
RPL23
Tbio
Novelty:  0.02741113
Score:  0.976
Data Source:  STRINGDB
RPL9
Tbio
Novelty:  0.00845583
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
signal recognition particle 72
694604
Mouse
MGI:1333795
66661
Dog
signal recognition particle 72
VGNC:46809
403944
Horse
signal recognition particle 72
VGNC:23589
100053755
Cow
signal recognition particle 72
VGNC:35287
509430
Species
Name
OMA
EggNOG
Inparanoid
Macaque
signal recognition particle 72
Mouse
Dog
signal recognition particle 72
Horse
signal recognition particle 72
Cow
signal recognition particle 72
Publication Statistics
PubMed Score 37.46
PubMed score by year
PubTator Score 25.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title