Tbio SRP14 Signal recognition particle 14 kDa protein

Protein Summary

Description

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Uniprot Accession IDs

• P37108
• B5BUF5
• Q6B0K5
• Q96Q14
• SRP14

Gene Name

• SRP14

Ensembl ID

• ENST00000267884
• ENSP00000267884
• ENSG00000140319

Symbol

• ALURBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
co-expressed gene	0.97
kinase perturbation	0.93
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Signal Recognition Particle 14 Kda Protein

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Signal Recognition Particle 14 Kda Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0