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Tchem
SRM
Spermidine synthase

Protein Summary
Description
Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376957
  • ENSP00000366156
  • ENSG00000116649

Symbol
  • SPS1
  • SRML1
  • PAPT
  • SPS1
  • SPDSY
  • SRML1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.89
transcription factor binding site profile
0.85
interacting protein
0.83
disease perturbation
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.47   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.47   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (90)
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
Score:  0.996
Data Source:  STRINGDB
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
Score:  0.995
Data Source:  STRINGDB
AGMAT
Tbio
Family:  Enzyme
Novelty:  0.03970349
Score:  0.978
Data Source:  STRINGDB
MTAP
Tchem
Family:  Enzyme
Novelty:  0.00485488
Score:  0.976
Data Source:  STRINGDB
SMOX
Tbio
Family:  Enzyme
Novelty:  0.0071711
Score:  0.973
Data Source:  STRINGDB
SAT1
Tbio
Family:  Enzyme
Novelty:  0.0022456
Score:  0.971
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.97
Data Source:  STRINGDB
SMS
Tchem
Family:  Enzyme
Novelty:  0.02447112
Score:  0.948
Data Source:  STRINGDB
SAT2
Tbio
Family:  Enzyme
Novelty:  0.10019856
Score:  0.938
Data Source:  STRINGDB
AZIN2
Tbio
Family:  Enzyme
Novelty:  0.00750311
Score:  0.886
Data Source:  STRINGDB
Pathways (27)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
4
4
97.2
balding measurement
2
2
2
95.8
3
3
1
1.3
95.7
corneal topography
4
2
4
92.6
heel bone mineral density
3
3
4
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
97.2
balding measurement
2
95.8
1
1.3
95.7
corneal topography
4
92.6
heel bone mineral density
4
89.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spermidine synthase
714028
Mouse
MGI:102690
20810
Dog
spermidine synthase
VGNC:46805
608702
Horse
spermidine synthase
VGNC:23584
100056730
Cow
spermidine synthase
VGNC:35282
505916
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spermidine synthase
Mouse
Dog
spermidine synthase
Horse
spermidine synthase
Cow
spermidine synthase
Publication Statistics
PubMed Score 46.47
PubMed score by year
PubTator Score 65.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title