Tbio SRF Serum response factor

Protein Summary

Description

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• P11831
• Q5T648
• SRF

Gene Name

• SRF

Ensembl ID

• ENST00000265354
• ENSP00000265354
• ENSG00000112658

Symbol

• MCM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
kinase	0.99
molecular function	0.98
transcription factor binding site profile	0.85

Protein Classes

PANTHER Classes

Protein / ... / Mads Box Transcription Factor / Serum Response Factor

DTO Classes

Protein / Transcription Factor / Mads Box Transcription Factor / Serum Response Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1070.49   (req: < 5)

Gene RIFs: 121   (req: <= 3)

Antibodies: 617   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1070.49   (req: >= 5)

Gene RIFs: 121   (req: > 3)

Antibodies: 617   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 88

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0