Tdark SREK1IP1 Protein SREK1IP1

Protein Summary

Description

Possible splicing regulator involved in the control of cellular survival.

Uniprot Accession IDs

• Q8N9Q2
• Q32NC8

Gene Name

• SREK1IP1

Ensembl ID

• ENST00000513458
• ENSP00000427401
• ENSG00000153006

Symbol

• P18SRP
• SFRS12IP1
• P18SRP
• SFRS12IP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.93
histone modification site profile	0.88
transcription factor binding site profile	0.75
small molecule perturbation	0.69
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.95   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 52   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.95   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (56)

Explore Interacting Targets

1 – 10 of 56

• See Interactions on String-DB

MAP1A

Tbio

Novelty:  0.00660165

p_int:  0.999929366

p_ni:  0.000054045

p_wrong:  0.000016589

Score:  0.187

Data Source:  BioPlex,STRINGDB

CSNK2A2

Tchem

Family:  Kinase

Novelty:  0.00231447

p_int:  0.998915129

p_ni:  0.001084871

Data Source:  BioPlex

CSNK2A1

Tchem

Family:  Kinase

Novelty:  0.00187855

p_int:  0.995975348

p_ni:  0.004024652

Data Source:  BioPlex

RABL6

Tbio

Family:  Enzyme

Novelty:  0.11501478

p_int:  0.994558908

p_ni:  0.005365033

p_wrong:  0.000076059

Score:  0.197

Data Source:  BioPlex,STRINGDB

C1orf131

Tdark

Novelty:  10.11904762

p_int:  0.993035334

p_ni:  0.006964666

Score:  0.188

Data Source:  BioPlex,STRINGDB

FTL

Tbio

Novelty:  0.00235168

p_int:  0.986202193

p_ni:  0.013797807

Score:  0.392

Data Source:  BioPlex,STRINGDB

NOS1AP

Tbio

Family:  Enzyme

Novelty:  0.0076555

p_int:  0.981101409

p_ni:  0.018898591

Score:  0.303

Data Source:  BioPlex,STRINGDB

NUP153

Tbio

Novelty:  0.00696568

p_int:  0.896144971

p_ni:  0.103855029

p_wrong:  1e-9

Score:  0.175

Data Source:  BioPlex,STRINGDB

KPNA5

Tbio

Novelty:  0.0762372

p_int:  0.893455732

p_ni:  0.106544268

Score:  0.204

Data Source:  BioPlex,STRINGDB

KPNA6

Tbio

Novelty:  0.03516499

p_int:  0.877631241

p_ni:  0.122368759

Score:  0.16

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Processes (2)

Find Similar Targets

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1 – 2 of 2

GO Term	Evidence	Assigned by
nucleic acid binding	Inferred from Electronic Annotation (IEA)	InterPro
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	3	3	3		71.4
bladder carcinoma	EFO_0000292	1	1	0	1.4	46.9
cognitive function measurement	EFO_0008354	3	1	3		45.7
self reported educational attainment	EFO_0004784	1	1	1		44.2
systolic blood pressure	EFO_0006335	1	1	1		38.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	3		71.4
bladder carcinoma	EFO_0000292	0	1.4	46.9
cognitive function measurement	EFO_0008354	3		45.7
self reported educational attainment	EFO_0004784	1		44.2
systolic blood pressure	EFO_0006335	1		38.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Metal-binding
mRNA processing
mRNA splicing
Phosphoprotein
Reference proteome
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
bladder carcinoma
body height
body mass index
chronotype measurement
cognitive function measurement
comparative body size at age 10, self-reported
intelligence
self reported educational attainment
systolic blood pressure

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SREK1 interacting protein 1	VGNC:7156	743558
Macaque	SREK1 interacting protein 1		695436
Mouse	splicing regulatory glutamine/lysine-rich protein 1interacting protein 1	MGI:1914538	67288
Rat	CG3918-like	RGD:2323713	100362980
Dog	SREK1 interacting protein 1	VGNC:46798	609639

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SREK1 interacting protein 1
Macaque	SREK1 interacting protein 1
Mouse	splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
Rat	CG3918-like
Dog	SREK1 interacting protein 1

Publication Statistics

PubMed Score 0.95

PubMed score by year

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PubTator Score 0.73

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title