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Tdark
SREK1IP1
Protein SREK1IP1

Protein Summary
Description
Possible splicing regulator involved in the control of cellular survival.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000513458
  • ENSP00000427401
  • ENSG00000153006

Symbol
  • P18SRP
  • SFRS12IP1
  • P18SRP
  • SFRS12IP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.93
histone modification site profile
0.88
transcription factor binding site profile
0.75
small molecule perturbation
0.69
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
MAP1A
Tbio
Novelty:  0.00660165
p_int:  0.999929366
p_ni:  0.000054045
p_wrong:  0.000016589
Score:  0.187
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.998915129
p_ni:  0.001084871
Data Source:  BioPlex
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.995975348
p_ni:  0.004024652
Data Source:  BioPlex
RABL6
Tbio
Family:  Enzyme
Novelty:  0.11501478
p_int:  0.994558908
p_ni:  0.005365033
p_wrong:  0.000076059
Score:  0.197
Data Source:  BioPlex,STRINGDB
C1orf131
Tdark
Novelty:  10.11904762
p_int:  0.993035334
p_ni:  0.006964666
Score:  0.188
Data Source:  BioPlex,STRINGDB
FTL
Tbio
Novelty:  0.00235168
p_int:  0.986202193
p_ni:  0.013797807
Score:  0.392
Data Source:  BioPlex,STRINGDB
NOS1AP
Tbio
Family:  Enzyme
Novelty:  0.0076555
p_int:  0.981101409
p_ni:  0.018898591
Score:  0.303
Data Source:  BioPlex,STRINGDB
NUP153
Tbio
Novelty:  0.00696568
p_int:  0.896144971
p_ni:  0.103855029
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
KPNA5
Tbio
Novelty:  0.0762372
p_int:  0.893455732
p_ni:  0.106544268
Score:  0.204
Data Source:  BioPlex,STRINGDB
KPNA6
Tbio
Novelty:  0.03516499
p_int:  0.877631241
p_ni:  0.122368759
Score:  0.16
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
3
3
71.4
1
1
0
1.4
46.9
cognitive function measurement
3
1
3
45.7
self reported educational attainment
1
1
1
44.2
systolic blood pressure
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
71.4
0
1.4
46.9
cognitive function measurement
3
45.7
self reported educational attainment
1
44.2
systolic blood pressure
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SREK1 interacting protein 1
VGNC:7156
743558
Macaque
SREK1 interacting protein 1
695436
Mouse
MGI:1914538
67288
Rat
RGD:2323713
100362980
Dog
SREK1 interacting protein 1
VGNC:46798
609639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SREK1 interacting protein 1
Macaque
SREK1 interacting protein 1
Mouse
Rat
Dog
SREK1 interacting protein 1
Publication Statistics
PubMed Score 0.95
PubMed score by year
PubTator Score 0.73
PubTator score by year
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Related Publications
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PMID
Year
Title