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Tbio
SREK1
Splicing regulatory glutamine/lysine-rich protein 1

Protein Summary
Description
Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334121
  • ENSP00000334538
  • ENSG00000153914
  • ENST00000380918
  • ENSP00000370305

Symbol
  • SFRS12
  • SRRP86
  • SFRS12
  • SRrp86
  • SRrp508
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.97
microRNA
0.75
transcription factor binding site profile
0.73
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
PUF60
Tbio
Novelty:  0.02667356
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.928
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.99999981
p_ni:  1.9e-7
Score:  0.61
Data Source:  BioPlex,STRINGDB
ZRANB2
Tbio
Novelty:  0.06105086
p_int:  0.999307745
p_ni:  0.000692255
Score:  0.727
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.998033034
p_ni:  0.001966966
Data Source:  BioPlex
SRSF8
Tbio
Novelty:  0.16509556
p_int:  0.996939242
p_ni:  0.0030594
p_wrong:  0.000001358
Score:  0.777
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.982389814
p_ni:  0.017610186
Score:  0.756
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.977432777
p_ni:  0.022567219
p_wrong:  4e-9
Data Source:  BioPlex
CDX1
Tbio
Family:  TF
Novelty:  0.00815821
p_int:  0.972777626
p_ni:  0.026997597
p_wrong:  0.000224777
Data Source:  BioPlex
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.956901221
p_ni:  0.042779538
p_wrong:  0.000319241
Score:  0.156
Data Source:  BioPlex,STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.956219414
p_ni:  0.043557377
p_wrong:  0.000223209
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multisite chronic pain
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multisite chronic pain
1
1.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing regulatory glutamic acid and lysine rich protein 1
VGNC:13600
461839
Macaque
splicing regulatory glutamic acid and lysine rich protein 1
697731
Mouse
MGI:2145245
218543
Rat
RGD:621696
56763
Dog
splicing regulatory glutamic acid and lysine rich protein 1
VGNC:46797
487233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing regulatory glutamic acid and lysine rich protein 1
Macaque
splicing regulatory glutamic acid and lysine rich protein 1
Mouse
Rat
Dog
splicing regulatory glutamic acid and lysine rich protein 1
Publication Statistics
PubMed Score 5.85
PubMed score by year
PubTator Score 5.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title