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Tclin
SRC
Proto-oncogene tyrosine-protein kinase Src

Protein Summary
Description
Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358208
  • ENSP00000350941
  • ENSG00000197122
  • ENST00000373558
  • ENSP00000362659
  • ENST00000373567
  • ENSP00000362668
  • ENST00000373578
  • ENSP00000362680

Symbol
  • SRC1
  • ASV
  • SRC1
  • THC6
  • c-SRC
  • p60-Src
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10839.3   (req: < 5)
Gene RIFs: 649   (req: <= 3)
Antibodies: 1782   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10839.3   (req: >= 5)
Gene RIFs: 649   (req: > 3)
Antibodies: 1782   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 132
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 821
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (1253)
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
p_int:  0.999993256
p_ni:  0.00000671
p_wrong:  3.4e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRUNE2
Tbio
Novelty:  0.05701865
p_int:  0.999820003
p_ni:  0.000179993
p_wrong:  3e-9
Score:  0.678
Data Source:  BioPlex,STRINGDB
ACBD7
Tdark
Novelty:  0.32019061
p_int:  0.999781684
p_ni:  0.000218315
p_wrong:  1e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
CCNL2
Tbio
Novelty:  0.03667817
p_int:  0.999736191
p_ni:  0.000263809
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.999710758
p_ni:  0.000289242
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.999703111
p_ni:  0.000296889
Score:  0.152
Data Source:  BioPlex,STRINGDB
RASEF
Tbio
Novelty:  0.08877022
p_int:  0.999576873
p_ni:  0.000423127
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.999569861
p_ni:  0.000430139
Score:  0.254
Data Source:  BioPlex,STRINGDB
SDHD
Tbio
Family:  Enzyme
Novelty:  0.00167904
p_int:  0.99881591
p_ni:  0.001184078
p_wrong:  1.2e-8
Data Source:  BioPlex
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.997831299
p_ni:  0.002168697
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (303)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 144
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Activated NTRK2 signals through FYN
Reactome
Activated NTRK3 signals through PI3K
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Activated NTRK2 signals through FYN
Activated NTRK3 signals through PI3K
Activation of NMDA receptors and postsynaptic events
Adaptive Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (151)
Find Similar Targets
Items per page:
10
1 – 10 of 25
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
37.6
appendicular lean mass
1
1
1
13
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
37.6
appendicular lean mass
1
13
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRC proto-oncogene, non-receptor tyrosine kinase
VGNC:10269
458229
Macaque
SRC proto-oncogene, non-receptor tyrosine kinase
701057
Mouse
MGI:98397
20779
Rat
RGD:620795
83805
Dog
SRC proto-oncogene, non-receptor tyrosine kinase
VGNC:46791
485864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRC proto-oncogene, non-receptor tyrosine kinase
Macaque
SRC proto-oncogene, non-receptor tyrosine kinase
Mouse
Rat
Dog
SRC proto-oncogene, non-receptor tyrosine kinase
Publication Statistics
PubMed Score 10839.30
PubMed score by year
PubTator Score 4012.11
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title