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Tchem
SQOR
Sulfide:quinone oxidoreductase, mitochondrial

Protein Summary
Description
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260324
  • ENSP00000260324
  • ENSG00000137767
  • ENST00000568606
  • ENSP00000456019

Symbol
  • SQRDL
  • SQR
  • SQRDL
  • CGI-44
  • PRO1975
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.59   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.59   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SLC45A2
Tbio
Family:  Transporter
Novelty:  0.00268252
p_int:  0.999999725
p_ni:  2.75e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
CABP5
Tbio
Novelty:  0.10488887
p_int:  0.999996559
p_ni:  0.00000343
p_wrong:  1.1e-8
Data Source:  BioPlex
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
p_int:  0.999995185
p_ni:  0.000004815
Data Source:  BioPlex
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.999893085
p_ni:  0.00010664
p_wrong:  2.75e-7
Data Source:  BioPlex
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.999046415
p_ni:  0.000376983
p_wrong:  0.000576602
Score:  0.167
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.998621884
p_ni:  0.000886012
p_wrong:  0.000492104
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.997858452
p_ni:  0.001281042
p_wrong:  0.000860506
Score:  0.172
Data Source:  BioPlex,STRINGDB
ETHE1
Tbio
Family:  Enzyme
Novelty:  0.01397214
Score:  0.98
Data Source:  Reactome,STRINGDB
TST
Tchem
Family:  Enzyme
Novelty:  0.00214991
Score:  0.974
Data Source:  Reactome,STRINGDB
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
Score:  0.767
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
1
1
60.5
glomerular filtration rate
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
60.5
glomerular filtration rate
1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfide quinone oxidoreductase
453405
Macaque
sulfide quinone oxidoreductase
713699
Mouse
MGI:1929899
59010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfide quinone oxidoreductase
Macaque
sulfide quinone oxidoreductase
Mouse
Publication Statistics
PubMed Score 381.59
PubMed score by year
PubTator Score 6.83
PubTator score by year
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Related Publications
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PMID
Year
Title