Protein Summary
Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231). Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increas ...more
- ENST00000256969
- ENSP00000256969
- ENSG00000134548
- C12orf39
- C12orf39
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.79 | ||
cellular component | 0.61 | ||
cell line | 0.57 | ||
biological process | 0.49 | ||
biological term | 0.36 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 251.34 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 20 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 251.34 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 20 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
bilirubin measurement | 2 | 8 | 15 | 94.5 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 72.3 | |||||
hemoglobin measurement | 2 | 2 | 2 | 66.6 | |||||
mean platelet volume | 2 | 2 | 2 | 60.8 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 57.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
bilirubin measurement | 15 | 94.5 | |||||
serum gamma-glutamyl transferase measurement | 1 | 72.3 | |||||
hemoglobin measurement | 2 | 66.6 | |||||
mean platelet volume | 2 | 60.8 | |||||
C-reactive protein measurement | 1 | 57.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | spexin hormone | VGNC:5598 | 741806 | |||||
Mouse | MGI:2442262 | 319552 | ||||||
Dog | spexin hormone | VGNC:46784 | 102151474 | |||||
Horse | spexin hormone | VGNC:23564 | 100147193 | |||||
Cow | spexin hormone | VGNC:35262 | 509493 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | spexin hormone | |||||
Mouse | ||||||
Dog | spexin hormone | |||||
Horse | spexin hormone | |||||
Cow | spexin hormone | |||||
Publication Statistics
PubMed Score 251.34
PubMed score by year
PubTator Score 51.98
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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