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Tbio
SPX
Spexin

Protein Summary
Description
Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231). Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256969
  • ENSP00000256969
  • ENSG00000134548

Symbol
  • C12orf39
  • C12orf39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
cellular component
0.61
cell line
0.57
biological process
0.49
biological term
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.34   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.34   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
XPR1
Tbio
Novelty:  0.00735578
Score:  0.792
Data Source:  STRINGDB
CLPP
Tchem
Family:  Enzyme
Novelty:  0.00105289
Score:  0.736
Data Source:  STRINGDB
GPR152
Tbio
Family:  GPCR
Novelty:  0.02032351
Score:  0.709
Data Source:  STRINGDB
CLPX
Tbio
Family:  Enzyme
Novelty:  0.00254331
Score:  0.7
Data Source:  STRINGDB
SLC37A2
Tbio
Family:  Transporter
Novelty:  0.08172762
Score:  0.656
Data Source:  STRINGDB
SLC37A3
Tdark
Family:  Transporter
Novelty:  0.21571546
Score:  0.618
Data Source:  STRINGDB
GDPGP1
Tbio
Family:  Enzyme
Novelty:  0.01138425
Score:  0.581
Data Source:  STRINGDB
GALR1
Tchem
Family:  GPCR
Novelty:  0.00733469
Score:  0.58
Data Source:  STRINGDB
ALDH16A1
Tdark
Family:  Enzyme
Novelty:  0.21880567
Score:  0.558
Data Source:  STRINGDB
GYS2
Tbio
Family:  Enzyme
Novelty:  0.01522741
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
8
15
94.5
serum gamma-glutamyl transferase measurement
1
1
1
72.3
hemoglobin measurement
2
2
2
66.6
mean platelet volume
2
2
2
60.8
C-reactive protein measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
15
94.5
serum gamma-glutamyl transferase measurement
1
72.3
hemoglobin measurement
2
66.6
mean platelet volume
2
60.8
C-reactive protein measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spexin hormone
VGNC:5598
741806
Mouse
MGI:2442262
319552
Dog
spexin hormone
VGNC:46784
102151474
Horse
spexin hormone
VGNC:23564
100147193
Cow
spexin hormone
VGNC:35262
509493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spexin hormone
Mouse
Dog
spexin hormone
Horse
spexin hormone
Cow
spexin hormone
Publication Statistics
PubMed Score 251.34
PubMed score by year
PubTator Score 51.98
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title