You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SPTY2D1
Protein SPT2 homolog

Protein Summary
Description
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026).
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
histone modification site profile
0.88
cell type or tissue
0.81
microRNA
0.69
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.44   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.44   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.998780662
p_ni:  0.001219338
Score:  0.517
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.99740549
p_ni:  0.002594488
p_wrong:  2.2e-8
Data Source:  BioPlex
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.991872438
p_ni:  0.008127562
Score:  0.313
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.991214626
p_ni:  0.008785374
Score:  0.253
Data Source:  BioPlex,STRINGDB
ZNF692
Tbio
Family:  TF
Novelty:  0.07012646
p_int:  0.970852216
p_ni:  0.029147784
Data Source:  BioPlex
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.963782531
p_ni:  0.036217468
Data Source:  BioPlex
NIFK
Tbio
Novelty:  0.01221562
p_int:  0.956057015
p_ni:  0.043942985
Score:  0.196
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.95226716
p_ni:  0.04773284
Data Source:  BioPlex
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.945898989
p_ni:  0.054101005
p_wrong:  6e-9
Data Source:  BioPlex
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.945011636
p_ni:  0.054988363
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
4
5
92.6
total cholesterol measurement
3
3
6
73.8
Myopia
1
1
0
1.1
55.2
body height
1
1
1
44.2
refractive error measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
92.6
total cholesterol measurement
6
73.8
Myopia
0
1.1
55.2
body height
1
44.2
refractive error measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPT2 chromatin protein domain containing 1
VGNC:996
451067
Macaque
SPT2 chromatin protein domain containing 1
693282
Mouse
MGI:2142062
101685
Rat
RGD:2319415
100365259
Dog
SPT2 chromatin protein domain containing 1
VGNC:46783
476884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPT2 chromatin protein domain containing 1
Macaque
SPT2 chromatin protein domain containing 1
Mouse
Rat
Dog
SPT2 chromatin protein domain containing 1
Publication Statistics
PubMed Score 1.44
PubMed score by year
PubTator Score 12.22
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title