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Tbio
SPTLC3
Serine palmitoyltransferase 3

Protein Summary
Description
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference. This gene encodes a subunit of the serine palmitoyltransferase complex which catalyzes the rate-limiting step in sphingolipid biosynthesis. This subunit metabolizes lauroyl- and myristoyl-CoA and generates C14 and C16-sphingoid bases. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399002
  • ENSP00000381968
  • ENSG00000172296

Symbol
  • C20orf38
  • SPTLC2L
  • LCB3
  • SPT3
  • LCB 3
  • LCB2B
  • SPT 3
  • hLCB2b
  • SPTLC2L
  • C20orf38
  • dJ718P11
  • dJ718P11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cellular component
0.69
cell type or tissue
0.66
small molecule perturbation
0.66
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.74   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.74   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
SPTSSA
Tbio
Family:  Enzyme
Novelty:  0.13352078
Score:  0.993
Data Source:  Reactome,STRINGDB
SPTSSB
Tdark
Family:  Enzyme
Novelty:  0.05967882
Score:  0.993
Data Source:  Reactome,STRINGDB
SPTLC1
Tchem
Family:  Enzyme
Novelty:  0.00639691
Score:  0.99
Data Source:  Reactome,STRINGDB
KDSR
Tbio
Family:  Enzyme
Novelty:  0.0408411
Score:  0.968
Data Source:  STRINGDB
ORMDL3
Tbio
Novelty:  0.00958976
Score:  0.938
Data Source:  STRINGDB
SPTLC2
Tchem
Family:  Enzyme
Novelty:  0.01236952
Score:  0.903
Data Source:  STRINGDB
ZDHHC9
Tbio
Family:  Enzyme
Novelty:  0.04949094
Score:  0.902
Data Source:  STRINGDB
GOLGA7
Tbio
Novelty:  0.17108842
Score:  0.9
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.831
Data Source:  STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.831
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
4
7
16
95.1
metabolite measurement
1
3
25
91.6
blood metabolite measurement
4
2
5
90.7
sphingolipid measurement
3
2
4
90.6
serum alanine aminotransferase measurement
2
3
2
7.6
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
16
95.1
metabolite measurement
25
91.6
blood metabolite measurement
5
90.7
sphingolipid measurement
4
90.6
serum alanine aminotransferase measurement
2
7.6
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine palmitoyltransferase long chain base subunit 3
VGNC:10000
735328
Macaque
serine palmitoyltransferase long chain base subunit 3
693775
Mouse
MGI:2444678
228677
Rat
RGD:1310030
296188
Dog
serine palmitoyltransferase long chain base subunit 3
VGNC:46781
485766
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine palmitoyltransferase long chain base subunit 3
Macaque
serine palmitoyltransferase long chain base subunit 3
Mouse
Rat
Dog
serine palmitoyltransferase long chain base subunit 3
Publication Statistics
PubMed Score 26.74
PubMed score by year
PubTator Score 6.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title