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Tbio
SPTBN2
Spectrin beta chain, non-erythrocytic 2

Protein Summary
Description
Probably plays an important role in neuronal membrane skeleton. Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309996
  • ENSP00000311489
  • ENSG00000173898
  • ENST00000529997
  • ENSP00000433593
  • ENST00000533211
  • ENSP00000432568

Symbol
  • KIAA0302
  • SCA5
  • SCA5
  • SCAR14
  • GTRAP41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cellular component
0.81
gene perturbation
0.76
cell line
0.73
small molecule perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.42   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.42   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (242)
SPTAN1
Tbio
Novelty:  0.00286901
Score:  0.975
Data Source:  STRINGDB
SPTA1
Tbio
Novelty:  0.00456741
Score:  0.953
Data Source:  STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.949
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.948
Data Source:  STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.944
Data Source:  STRINGDB
ACTR1A
Tbio
Novelty:  0.06306209
Score:  0.939
Data Source:  STRINGDB
ANK1
Tbio
Novelty:  0.00225305
Score:  0.938
Data Source:  STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.93
Data Source:  STRINGDB
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
Score:  0.928
Data Source:  STRINGDB
RILP
Tbio
Novelty:  0.08339816
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
COPI-mediated anterograde transport
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
Axon guidance
COPI-mediated anterograde transport
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
3
4
91.7
insomnia measurement
1
2
0
1.1
57.1
low density lipoprotein cholesterol measurement
1
1
1
49.5
apolipoprotein B measurement
1
1
1
46.9
IGF-1 measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
91.7
insomnia measurement
0
1.1
57.1
low density lipoprotein cholesterol measurement
1
49.5
apolipoprotein B measurement
1
46.9
IGF-1 measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spectrin beta, non-erythrocytic 2
VGNC:8187
451353
Macaque
spectrin beta, non-erythrocytic 2
713419
Mouse
MGI:1313261
20743
Rat
RGD:3751
29211
Dog
spectrin beta, non-erythrocytic 2
VGNC:46776
483706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spectrin beta, non-erythrocytic 2
Macaque
spectrin beta, non-erythrocytic 2
Mouse
Rat
Dog
spectrin beta, non-erythrocytic 2
Publication Statistics
PubMed Score 95.42
PubMed score by year
PubTator Score 36.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title