Tbio SPTAN1 Spectrin alpha chain, non-erythrocytic 1

Protein Summary

Description

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q13813
• Q13186
• Q15324
• Q16606
• Q59EF1
• Q5VXV5
• Q5VXV6
• Q7Z6M5
• Q9P0V0

Gene Name

• SPTAN1

Ensembl ID

• ENST00000358161
• ENSP00000350882
• ENSG00000197694
• ENST00000372731
• ENSP00000361816
• ENST00000372739
• ENSP00000361824

Symbol

• NEAS
• SPTA2
• NEAS
• EIEE5
• SPTA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
protein domain	0.97
kinase perturbation	0.96
transcription factor perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.15   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 427   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.15   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0