You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPSB1
SPRY domain-containing SOCS box protein 1

Protein Summary
Description
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328089
  • ENSP00000330221
  • ENSG00000171621
  • ENST00000357898
  • ENSP00000350573
  • ENST00000377399
  • ENSP00000366616

Symbol
  • SSB1
  • SSB1
  • SSB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
virus perturbation
0.85
transcription factor
0.8
disease
0.76
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.37   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.37   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
CISH
Tbio
Novelty:  0.00145893
Score:  0.974
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.969
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.959
Data Source:  STRINGDB
LRRC41
Tbio
Novelty:  0.12601472
Score:  0.953
Data Source:  STRINGDB
MEX3C
Tbio
Family:  Enzyme
Novelty:  0.13082235
Score:  0.947
Data Source:  STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.945
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.945
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.942
Data Source:  STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
Score:  0.941
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
11
12
93.7
waist-hip ratio
3
10
11
90.6
BMI-adjusted hip circumference
2
11
11
88.3
eosinophil percentage of leukocytes
2
3
3
87.3
childhood onset asthma
1
1
0
1.1
69.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
93.7
waist-hip ratio
11
90.6
BMI-adjusted hip circumference
11
88.3
eosinophil percentage of leukocytes
3
87.3
childhood onset asthma
0
1.1
69.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splA/ryanodine receptor domain and SOCS box containing 1
VGNC:9901
469790
Macaque
splA/ryanodine receptor domain and SOCS box containing 1
722211
Mouse
MGI:1921896
74646
Rat
RGD:1309319
313722
Dog
splA/ryanodine receptor domain and SOCS box containing 1
VGNC:46770
479598
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splA/ryanodine receptor domain and SOCS box containing 1
Macaque
splA/ryanodine receptor domain and SOCS box containing 1
Mouse
Rat
Dog
splA/ryanodine receptor domain and SOCS box containing 1
Publication Statistics
PubMed Score 10.37
PubMed score by year
PubTator Score 7.70
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title