You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPRR3
Small proline-rich protein 3

Protein Summary
Description
Cross-linked envelope protein of keratinocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295367
  • ENSP00000295367
  • ENSG00000163209
  • ENST00000331860
  • ENSP00000330391

Symbol
  • SPRC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
virus perturbation
0.64
cell type or tissue
0.54
transcription factor perturbation
0.54
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.13   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.13   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999991902
p_ni:  0.000008073
p_wrong:  2.5e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
HSF2
Tbio
Family:  TF
Novelty:  0.06458223
p_int:  0.999982301
p_ni:  0.000017481
p_wrong:  2.17e-7
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.999885147
p_ni:  0.000040049
p_wrong:  0.000074804
Data Source:  BioPlex
NSL1
Tbio
Novelty:  0.01396984
p_int:  0.999313074
p_ni:  0.000386391
p_wrong:  0.000300535
Score:  0.199
Data Source:  BioPlex,STRINGDB
JOSD2
Tbio
Novelty:  0.27109362
p_int:  0.98150845
p_ni:  0.018483847
p_wrong:  0.000007703
Score:  0.196
Data Source:  BioPlex,STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.985
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.981
Data Source:  STRINGDB
SPRR2A
Tbio
Novelty:  0.07065019
Score:  0.969
Data Source:  STRINGDB
SPRR1A
Tbio
Novelty:  0.04328986
Score:  0.968
Data Source:  STRINGDB
SPRR1B
Tbio
Novelty:  0.0320028
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
79.6
2
2
0
1.2
60.4
age at onset
1
1
1
32.8
granulocyte count
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
79.6
0
1.2
60.4
age at onset
1
32.8
granulocyte count
1
3.5
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small proline rich protein 3
VGNC:6999
469496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small proline rich protein 3
Publication Statistics
PubMed Score 50.13
PubMed score by year
PubTator Score 27.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title