Protein Summary
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage. The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]
- ENST00000307098
- ENSP00000306461
- ENSG00000169469
- SPRR1
- GADD33
- SPR-IB
- CORNIFIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.73 | ||
small molecule perturbation | 0.58 | ||
cell line | 0.5 | ||
interacting protein | 0.49 | ||
tissue | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.07 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.07 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
ITGA9
Novelty: 0.01488635
p_int: 0.996577108
p_ni: 0.00062981
p_wrong: 0.002793082
Score: 0.435
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.2 | 58.4 | |||||
age at onset | 1 | 1 | 1 | 32.8 | |||||
2 | 1 | 2 | 32.8 | ||||||
monocyte count | 1 | 1 | 1 | 10.3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 58.4 | |||||
age at onset | 1 | 32.8 | |||||
2 | 32.8 | ||||||
monocyte count | 1 | 10.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Cow | cornifin-B-like | 507527 | ||||||
Pig | small proline-rich protein | 397469 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Cow | cornifin-B-like | |||||
Pig | small proline-rich protein | |||||
Publication Statistics
PubMed Score 34.07
PubMed score by year
PubTator Score 24.56
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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