You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPRR1B
Cornifin-B

Protein Summary
Description
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage. The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307098
  • ENSP00000306461
  • ENSG00000169469

Symbol
  • SPRR1
  • GADD33
  • SPR-IB
  • CORNIFIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
small molecule perturbation
0.58
cell line
0.5
interacting protein
0.49
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.07   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.07   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
ITGA9
Tbio
Novelty:  0.01488635
p_int:  0.996577108
p_ni:  0.00062981
p_wrong:  0.002793082
Score:  0.435
Data Source:  BioPlex,STRINGDB
SPRR1A
Tbio
Novelty:  0.04328986
Score:  0.986
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.984
Data Source:  STRINGDB
SPRR2A
Tbio
Novelty:  0.07065019
Score:  0.978
Data Source:  STRINGDB
SPRR2D
Tdark
Novelty:  0.28543054
Score:  0.973
Data Source:  STRINGDB
SPRR2E
Tdark
Novelty:  0.78347788
Score:  0.972
Data Source:  STRINGDB
SPRR3
Tbio
Novelty:  0.0241484
Score:  0.968
Data Source:  STRINGDB
SPRR2B
Tdark
Novelty:  0.36342019
Score:  0.964
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.963
Data Source:  STRINGDB
TCHH
Tbio
Novelty:  0.00303837
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
58.4
age at onset
1
1
1
32.8
2
1
2
32.8
monocyte count
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
58.4
age at onset
1
32.8
2
32.8
monocyte count
1
10.3
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
cornifin-B-like
507527
Pig
small proline-rich protein
397469
Species
Name
OMA
EggNOG
Inparanoid
Cow
cornifin-B-like
Pig
small proline-rich protein
Publication Statistics
PubMed Score 34.07
PubMed score by year
PubTator Score 24.56
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title