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Tbio
SPRED2
Sprouty-related, EVH1 domain-containing protein 2

Protein Summary
Description
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356388
  • ENSP00000348753
  • ENSG00000198369
  • ENST00000443619
  • ENSP00000393697

Symbol
  • Spred-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
kinase perturbation
0.91
transcription factor
0.91
PubMedID
0.85
transcription factor perturbation
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
PDP1
Tbio
Family:  Enzyme
Novelty:  0.00442352
p_int:  0.999788673
p_ni:  0.000211327
Score:  0.189
Data Source:  BioPlex,STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.999772589
p_ni:  0.000227408
p_wrong:  3e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
PRTFDC1
Tbio
Family:  Enzyme
Novelty:  0.13607881
p_int:  0.992377425
p_ni:  0.000607319
p_wrong:  0.007015256
Score:  0.225
Data Source:  BioPlex,STRINGDB
RPS6KA3
Tchem
Family:  Kinase
Novelty:  0.00221219
p_int:  0.980912747
p_ni:  0.019087241
p_wrong:  1.1e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.858890299
p_ni:  0.035208841
p_wrong:  0.10590086
Score:  0.171
Data Source:  BioPlex,STRINGDB
RPS6KA2
Tchem
Family:  Kinase
Novelty:  0.00409407
p_int:  0.825155894
p_ni:  0.007477471
p_wrong:  0.167366636
Score:  0.221
Data Source:  BioPlex,STRINGDB
STOM
Tbio
Novelty:  0.00459891
p_int:  0.81677865
p_ni:  0.183219407
p_wrong:  0.000001943
Score:  0.188
Data Source:  BioPlex,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.788266419
p_ni:  0.195552591
p_wrong:  0.016180991
Data Source:  BioPlex
NF1
Tbio
Novelty:  0.00019092
Score:  0.928
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFRL1 modulation of FGFR1 signaling
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FGFRL1 modulation of FGFR1 signaling
FLT3 Signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
90.4
leukocyte count
2
2
2
90
basophil count
2
2
2
86.4
monocyte count
2
2
2
86.1
myeloid white cell count
2
2
2
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
90.4
leukocyte count
2
90
basophil count
2
86.4
monocyte count
2
86.1
myeloid white cell count
2
83.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2150019
114716
Rat
RGD:1309304
305539
Dog
sprouty related EVH1 domain containing 2
VGNC:46763
481397
Horse
sprouty related EVH1 domain containing 2
VGNC:23540
100062947
Cow
sprouty related EVH1 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:17722]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
sprouty related EVH1 domain containing 2
Horse
sprouty related EVH1 domain containing 2
Cow
sprouty related EVH1 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:17722]
Publication Statistics
PubMed Score 33.48
PubMed score by year
PubTator Score 12.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title