Tchem SPPL2B Signal peptide peptidase-like 2B

Protein Summary

Description

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TCT7
• D6W609
• O60365
• Q567S3
• Q8IUH9
• Q9BUY6
• Q9H3M4
• Q9NPN2
• Q9P1Z6
• SPP-like 2B

Gene Name

• SPPL2B

Ensembl ID

• ENST00000610743
• ENSP00000478510
• ENSG00000005206
• ENST00000613503
• ENSP00000478298
• ENST00000618220
• ENSP00000480813

Symbol

• IMP4
• KIAA1532
• PSL1
• IMP4
• PSH4
• PSL1
• IMP-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.85
histone modification site profile	0.76
tissue	0.67
kinase perturbation	0.66
transcription factor binding site profile	0.64

Protein Classes

PANTHER Classes

Protein / ... / Aspartic Protease / Signal Peptide Peptidase-like 2b

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Signal Peptide Peptidase-like 2b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.38   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.38   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0