You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SPPL2B
Signal peptide peptidase-like 2B

Protein Summary
Description
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610743
  • ENSP00000478510
  • ENSG00000005206
  • ENST00000613503
  • ENSP00000478298
  • ENST00000618220
  • ENSP00000480813

Symbol
  • IMP4
  • KIAA1532
  • PSL1
  • IMP4
  • PSH4
  • PSL1
  • IMP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.85
histone modification site profile
0.76
tissue
0.67
kinase perturbation
0.66
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (121)
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.999995648
p_ni:  0.000004352
Data Source:  BioPlex
PIGN
Tbio
Family:  Enzyme
Novelty:  0.02210783
p_int:  0.999963416
p_ni:  0.000036429
p_wrong:  1.54e-7
Data Source:  BioPlex
KTN1
Tbio
Novelty:  0.01436672
p_int:  0.999947902
p_ni:  0.000052098
Data Source:  BioPlex
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.999940761
p_ni:  0.000059202
p_wrong:  3.6e-8
Data Source:  BioPlex
SLC35G2
Tdark
Family:  Transporter
Novelty:  0.57896683
p_int:  0.999915549
p_ni:  0.000075975
p_wrong:  0.000008475
Data Source:  BioPlex
IGSF3
Tbio
Novelty:  0.07528465
p_int:  0.999914058
p_ni:  0.000085941
p_wrong:  1e-9
Data Source:  BioPlex
P2RX4
Tchem
Family:  IC
Novelty:  0.00242958
p_int:  0.999903309
p_ni:  0.000096569
p_wrong:  1.22e-7
Data Source:  BioPlex
TMEM8A
Tdark
Novelty:  0.15724279
p_int:  0.999838688
p_ni:  0.000075478
p_wrong:  0.000085834
Data Source:  BioPlex
PIGW
Tbio
Novelty:  0.0245774
p_int:  0.999771188
p_ni:  0.000228812
Data Source:  BioPlex
MTCH1
Tbio
Novelty:  0.12469914
p_int:  0.999714193
p_ni:  0.000285807
Score:  0.315
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Regulation of TNFR1 signaling
Reactome
Signal Transduction
Reactome
TNF signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Regulation of TNFR1 signaling
Signal Transduction
TNF signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
72.8
pulse pressure measurement
1
1
1
64
self reported educational attainment
1
1
1
44.2
body height
1
1
1
35
age-related hearing impairment
1
1
0
5.9
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
72.8
pulse pressure measurement
1
64
self reported educational attainment
1
44.2
body height
1
35
age-related hearing impairment
0
5.9
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal peptide peptidase like 2B
VGNC:13515
750100
Mouse
MGI:1920468
73218
Rat
RGD:1308556
362828
Dog
signal peptide peptidase like 2B
VGNC:46759
485071
Cow
signal peptide peptidase like 2B
VGNC:35235
504285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal peptide peptidase like 2B
Mouse
Rat
Dog
signal peptide peptidase like 2B
Cow
signal peptide peptidase like 2B
Publication Statistics
PubMed Score 35.92
PubMed score by year
PubTator Score 18.24
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title