Protein Summary
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000237623
- ENSP00000237623
- ENSG00000118785
- ENST00000360804
- ENSP00000354042
- ENST00000395080
- ENSP00000378517
- ENST00000614857
- ENSP00000477824
- BNSP
- OPN
- OPN
- BNSP
- BSPI
- ETA-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
PubMedID | 1 | ||
chemical | 0.96 | ||
transcription factor perturbation | 0.96 | ||
biological process | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7717.76 (req: < 5)
Gene RIFs: 854 (req: <= 3)
Antibodies: 1318 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7717.76 (req: >= 5)
Gene RIFs: 854 (req: > 3)
Antibodies: 1318 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (433)
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (45)
Reactome (15)
KEGG (7)
PathwayCommons (8)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Integrin cell surface interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Integrin cell surface interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (2)
Components (7)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 3 | 5 | 5 | 98.8 | |||||
heel bone mineral density | 2 | 4 | 5 | 96.9 | |||||
4 | 3 | 0 | 1.7 | 94.2 | |||||
bone density | 6 | 4 | 7 | 92.2 | |||||
renal system measurement | 1 | 1 | 1 | 79.7 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 5 | 98.8 | |||||
heel bone mineral density | 5 | 96.9 | |||||
0 | 1.7 | 94.2 | |||||
bone density | 7 | 92.2 | |||||
renal system measurement | 1 | 79.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | secreted phosphoprotein 1 | VGNC:693 | 461366 | |||||
Macaque | secreted phosphoprotein 1 | 704930 | ||||||
Mouse | MGI:98389 | 20750 | ||||||
Rat | RGD:3752 | 25353 | ||||||
Dog | secreted phosphoprotein 1 | VGNC:46756 | 478471 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | secreted phosphoprotein 1 | |||||
Macaque | secreted phosphoprotein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | secreted phosphoprotein 1 | |||||
Publication Statistics
PubMed Score 7717.76
PubMed score by year
PubTator Score 3108.32
PubTator score by year
Related Publications
Text Mined References (937)
GeneRif Annotations (854)
Items per page:
0 of 0
PMID | Year | Title |
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