Tbio SPP1 Osteopontin

Protein Summary

Description

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P10451
• B2RDA1
• Q15681
• Q15682
• Q15683
• Q4W597
• Q567T5
• Q8NBK2
• Q96IZ1

Gene Name

• SPP1

Ensembl ID

• ENST00000237623
• ENSP00000237623
• ENSG00000118785
• ENST00000360804
• ENSP00000354042
• ENST00000395080
• ENSP00000378517
• ENST00000614857
• ENSP00000477824

Symbol

• BNSP
• OPN
• OPN
• BNSP
• BSPI
• ETA-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
PubMedID	1
chemical	0.96
transcription factor perturbation	0.96
biological process	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9057.31   (req: < 5)

Gene RIFs: 1069   (req: <= 3)

Antibodies: 1318   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9057.31   (req: >= 5)

Gene RIFs: 1069   (req: > 3)

Antibodies: 1318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0