Tbio SPOUT1 Putative methyltransferase C9orf114

Protein Summary

Description

Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233).

Uniprot Accession IDs

• Q5T280
• Q0D2P6
• Q6P469
• Q6PGP9
• Q6PIJ1
• Q6PJV9

Gene Name

• SPOUT1

Ensembl ID

• ENST00000361256
• ENSP00000354812
• ENSG00000198917

Symbol

• C9orf114
• CENP32
• CENP-32
• HSPC109
• C9orf114

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.97   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.97   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0