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Tbio
SPOP
Speckle-type POZ protein

Protein Summary
Description
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347630
  • ENSP00000240327
  • ENSG00000121067
  • ENST00000393328
  • ENSP00000377001
  • ENST00000503676
  • ENSP00000420908
  • ENST00000504102
  • ENSP00000425905

Symbol
  • TEF2
  • BTBD32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor perturbation
0.94
disease perturbation
0.93
transcription factor binding site profile
0.87
transcription factor
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.29   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.29   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (199)
MYD88
Tbio
Novelty:  0.00037931
p_int:  0.999998405
p_ni:  0.000001595
Score:  0.545
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.999996176
p_ni:  0.000003824
Score:  0.158
Data Source:  BioPlex,STRINGDB
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999994994
p_ni:  0.000004969
p_wrong:  3.7e-8
Score:  0.267
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999935655
p_ni:  0.000064341
p_wrong:  4e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
SOST
Tclin
Novelty:  0.0009273
p_int:  0.999651631
p_ni:  0.000348365
p_wrong:  4e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999552519
p_ni:  0.000323111
p_wrong:  0.00012437
Score:  0.152
Data Source:  BioPlex,STRINGDB
MSRB3
Tbio
Family:  Enzyme
Novelty:  0.02843512
p_int:  0.998987629
p_ni:  0.000342217
p_wrong:  0.000670154
Score:  0.243
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.999
Data Source:  Reactome,STRINGDB
H2AFY
Tbio
Novelty:  0.01150729
Score:  0.983
Data Source:  STRINGDB
GLI2
Tchem
Family:  TF
Novelty:  0.00229126
Score:  0.978
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Hedgehog 'on' state (R-HSA-5632684)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
86.9
mean reticulocyte volume
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
86.9
mean reticulocyte volume
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
speckle type BTB/POZ protein
VGNC:9653
455106
Macaque
speckle type BTB/POZ protein
699711
Mouse
MGI:1343085
20747
Rat
RGD:1311613
287643
Dog
speckle type BTB/POZ protein
VGNC:46753
480548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
speckle type BTB/POZ protein
Macaque
speckle type BTB/POZ protein
Mouse
Rat
Dog
speckle type BTB/POZ protein
Publication Statistics
PubMed Score 198.29
PubMed score by year
PubTator Score 51.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title