Tbio SPOCK3 Testican-3

Protein Summary

Description

May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion. This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9BQ16
• B2R7M7
• B3KR67
• B4DGK5
• B4DHB4
• B4DHV3
• B4DI46
• B4DJY3
• E7EP61
• F5H099
• O75705
• Q6UW53
• Q96Q26

Gene Name

• SPOCK3

Ensembl ID

• ENST00000357154
• ENSP00000349677
• ENSG00000196104
• ENST00000357545
• ENSP00000350153
• ENST00000421836
• ENSP00000411344
• ENST00000502330
• ENSP00000423606
• ENST00000504953
• ENSP00000425570
• ENST00000506886
• ENSP00000420920
• ENST00000510741
• ENSP00000426716
• ENST00000511269
• ENSP00000425502
• ENST00000511531
• ENSP00000423421
• ENST00000512648
• ENSP00000426177
• ENST00000512681
• ENSP00000426318
• ENST00000541354
• ENSP00000444789

Symbol

• TICN3
• TES-3
• TICN3
• HSAJ1454

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.75
disease perturbation	0.74
microRNA	0.72
PubMedID	0.66
molecular function	0.63

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Testican-3

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Testican-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.32   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.32   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0