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Tbio
SPOCK3
Testican-3

Protein Summary
Description
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion. This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357154
  • ENSP00000349677
  • ENSG00000196104
  • ENST00000357545
  • ENSP00000350153
  • ENST00000421836
  • ENSP00000411344
  • ENST00000502330
  • ENSP00000423606
  • ENST00000504953
  • ENSP00000425570
  • ENST00000506886
  • ENSP00000420920
  • ENST00000510741
  • ENSP00000426716
  • ENST00000511269
  • ENSP00000425502
  • ENST00000511531
  • ENSP00000423421
  • ENST00000512648
  • ENSP00000426177
  • ENST00000512681
  • ENSP00000426318
  • ENST00000541354
  • ENSP00000444789

Symbol
  • TICN3
  • TES-3
  • TICN3
  • HSAJ1454
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
disease perturbation
0.74
microRNA
0.72
PubMedID
0.66
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.77   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.77   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
Score:  0.968
Data Source:  STRINGDB
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
Score:  0.936
Data Source:  STRINGDB
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
Score:  0.902
Data Source:  STRINGDB
SPARC
Tbio
Novelty:  0.00063267
Score:  0.858
Data Source:  STRINGDB
CCDC14
Tdark
Novelty:  0.62617082
Score:  0.783
Data Source:  STRINGDB
MMP16
Tchem
Family:  Enzyme
Novelty:  0.01028533
Score:  0.759
Data Source:  STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
Score:  0.693
Data Source:  STRINGDB
SMOC2
Tbio
Novelty:  0.03698108
Score:  0.679
Data Source:  STRINGDB
ANXA10
Tbio
Novelty:  0.01232803
Score:  0.675
Data Source:  STRINGDB
SMOC1
Tbio
Novelty:  0.03819681
Score:  0.675
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
1
2
24.5
BMI-adjusted hip circumference
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
24.5
BMI-adjusted hip circumference
1
5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
VGNC:48929
461594
Macaque
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
705964
Mouse
MGI:1920152
72902
Rat
RGD:1305672
306404
Dog
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
VGNC:54224
482676
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
Macaque
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
Mouse
Rat
Dog
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
Publication Statistics
PubMed Score 8.77
PubMed score by year
PubTator Score 7.84
PubTator score by year
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Related Publications
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PMID
Year
Title