Protein Summary
Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activ ...more
- ENST00000360121
- ENSP00000353238
- ENSG00000197471
- ENST00000395389
- ENSP00000378787
- ENST00000563039
- ENSP00000455266
- CD43
- LSN
- CD43
- GALGP
- GPL115
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue sample | 0.76 | ||
transcription factor | 0.74 | ||
small molecule perturbation | 0.7 | ||
cell type or tissue | 0.65 | ||
cellular component | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 782.61 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 2013 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 782.61 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 2013 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (174)
EIF2B3
Novelty: 0.04963646
p_int: 0.870528449
p_ni: 0.129471551
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC39A11
Family: Transporter
Novelty: 0.09770302
p_int: 0.769156735
p_ni: 0.230843096
p_wrong: 1.7e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
SPAG9
Family: Enzyme
Novelty: 0.00527315
p_int: 0.759229447
p_ni: 0.240770553
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Basigin interactions | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Basigin interactions | ||||
Cell surface interactions at the vascular wall | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (3)
Components (9)
Processes (15)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 2 | 2 | 75.6 | |||||
platelet count | 1 | 1 | 1 | 13.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet crit | 2 | 75.6 | |||||
platelet count | 1 | 13.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | sialophorin | 467939 | ||||||
Macaque | sialophorin | 709860 | ||||||
Mouse | MGI:98384 | 20737 | ||||||
Rat | RGD:1559964 | 498157 | ||||||
Horse | sialophorin | VGNC:52027 | 100065743 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | sialophorin | |||||
Macaque | sialophorin | |||||
Mouse | ||||||
Rat | ||||||
Horse | sialophorin | |||||
Publication Statistics
PubMed Score 782.61
PubMed score by year
PubTator Score 376.93
PubTator score by year
Related Publications
Text Mined References (74)
GeneRif Annotations (47)
Items per page:
0 of 0
PMID | Year | Title |
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