Tbio SPN Leukosialin

Protein Summary

Description

Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). CD43 cytoplasmic tail: Protects cells from apoptotic signals, promoting cell survival. This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]

Uniprot Accession IDs

• P16150
• A8K9B1

Gene Name

• SPN

Ensembl ID

• ENST00000360121
• ENSP00000353238
• ENSG00000197471
• ENST00000395389
• ENSP00000378787
• ENST00000563039
• ENSP00000455266

Symbol

• CD43
• LSN
• CD43
• GALGP
• GPL115

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.76
transcription factor	0.74
small molecule perturbation	0.7
cell type or tissue	0.65
cellular component	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.61   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 2013   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.61   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 2013   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (174)

Explore Interacting Targets

1 – 10 of 174

• See Interactions on String-DB

EIF2B3

Tbio

Novelty:  0.04963646

p_int:  0.870528449

p_ni:  0.129471551

Score:  0.187

Data Source:  BioPlex,STRINGDB

SLC39A11

Tbio

Family:  Transporter

Novelty:  0.09770302

p_int:  0.769156735

p_ni:  0.230843096

p_wrong:  1.7e-7

Score:  0.187

Data Source:  BioPlex,STRINGDB

SPAG9

Tbio

Family:  Enzyme

Novelty:  0.00527315

p_int:  0.759229447

p_ni:  0.240770553

Score:  0.189

Data Source:  BioPlex,STRINGDB

SELE

Tchem

Novelty:  0.00029494

Score:  0.968

Data Source:  Reactome,STRINGDB

BSG

Tbio

Novelty:  0.0010285

Score:  0.952

Data Source:  Reactome,STRINGDB

SIGLEC1

Tbio

Novelty:  0.00369952

Score:  0.937

Data Source:  STRINGDB

PTPRC

Tchem

Family:  Enzyme

Novelty:  0.00012027

Score:  0.88

Data Source:  STRINGDB

CD5

Tbio

Novelty:  0.00032883

Score:  0.877

Data Source:  STRINGDB

CD19

Tclin

Novelty:  0.0001816

Score:  0.834

Data Source:  STRINGDB

MSN

Tbio

Novelty:  0.00178275

Score:  0.833

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Basigin interactions	25 targets	R-HSA-210991
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Basigin interactions	25 targets	R-HSA-210991
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (3)

Components (9)

Processes (15)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
heat shock protein binding	Inferred from Physical Interaction (IPI)	CAFA
Hsp70 protein binding	Inferred from Physical Interaction (IPI)	CAFA
transmembrane signaling receptor activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	2	2	2		75.6
platelet count	EFO_0004309	1	1	1		13.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	2		75.6
platelet count	EFO_0004309	1		13.6

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell projection
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
platelet count
platelet crit

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype
neoplasm

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	sialophorin		467939
Macaque	sialophorin		709860
Mouse	sialophorin	MGI:98384	20737
Rat	similar to Leukosialin precursor (Leucocyte sialoglycoprotein) (Sialophorin) (CD43) (W3/13 antigen)	RGD:1559964	498157
Horse	sialophorin	VGNC:52027	100065743

Species	Name	OMA	EggNOG	Inparanoid
Chimp	sialophorin
Macaque	sialophorin
Mouse	sialophorin
Rat	similar to Leukosialin precursor (Leucocyte sialoglycoprotein) (Sialophorin) (CD43) (W3/13 antigen)
Horse	sialophorin

Publication Statistics

PubMed Score 782.61

PubMed score by year

Reset Zoom

PubTator Score 376.93

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (74)

GeneRif Annotations (47)

Items per page:

10

0 of 0

PMID	Year	Title