Tbio SPIRE1 Protein spire homolog 1

Protein Summary

Description

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q08AE8
• A8K2B5
• J3KQ50
• J3KQR5
• Q1RMD4
• Q8NDP1
• Q9NQ71
• Q9ULT4
• Spir-1

Gene Name

• SPIRE1

Ensembl ID

• ENST00000409402
• ENSP00000387266
• ENSG00000134278
• ENST00000410092
• ENSP00000387226
• ENST00000440472
• ENSP00000404752
• ENST00000453447
• ENSP00000407050

Symbol

• KIAA1135
• SPIR1
• Spir-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
ligand (protein) perturbation	0.83
microRNA	0.82
kinase perturbation	0.81
histone modification site profile	0.73

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Protein Spire Homolog 1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Protein Spire Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.75   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.75   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0