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Tdark
SPINDOC
Spindlin interactor and repressor of chromatin-binding protein

Protein Summary
Description
Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294244
  • ENSP00000294244
  • ENSG00000168005

Symbol
  • C11orf84
  • C11orf84
  • SPIN-DOC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
SPIN1
Tchem
Novelty:  0.00889909
p_int:  1
Score:  0.91
Data Source:  BioPlex,STRINGDB
SPIN2B
Tchem
Novelty:  0.23202718
p_int:  1
Score:  0.795
Data Source:  BioPlex,STRINGDB
SPIN3
Tchem
Novelty:  0.16670763
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.537
Data Source:  BioPlex,STRINGDB
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.985458613
p_ni:  0.014529737
p_wrong:  0.000011651
Data Source:  BioPlex
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.982763213
p_ni:  0.017236787
Score:  0.187
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.91208284
p_ni:  0.087889478
p_wrong:  0.000027682
Score:  0.185
Data Source:  BioPlex,STRINGDB
MARK2
Tchem
Family:  Kinase
Novelty:  0.00437762
Score:  0.572
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.553
Data Source:  STRINGDB
ARHGAP8
Tbio
Family:  Enzyme
Novelty:  0.22016818
Score:  0.54
Data Source:  STRINGDB
RIPOR2
Tbio
Novelty:  0.0713762
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
2
42.3
1
1
0
1
21.5
1
1
0
1
21.5
low density lipoprotein cholesterol measurement
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
2
42.3
0
1
21.5
0
1
21.5
low density lipoprotein cholesterol measurement
1
5.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spindlin interactor and repressor of chromatin binding
VGNC:3189
451283
Macaque
chromosome 14 open reading frame, human C11orf84
718112
Mouse
MGI:2147611
68229
Rat
RGD:1308106
361719
Cow
spindlin interactor and repressor of chromatin binding
VGNC:50753
513662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spindlin interactor and repressor of chromatin binding
Macaque
chromosome 14 open reading frame, human C11orf84
Mouse
Rat
Cow
spindlin interactor and repressor of chromatin binding
Publication Statistics
PubMed Score 2.18
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
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PMID
Year
Title