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Tchem
SPIN3
Spindlin-3

Protein Summary
Description
Exhibits H3K4me3-binding activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374919
  • ENSP00000364054
  • ENSG00000204271
  • ENST00000475785
  • ENSP00000436805
  • ENST00000478405
  • ENSP00000433337
  • ENST00000638257
  • ENSP00000492795
  • ENST00000638289
  • ENSP00000491751
  • ENST00000638386
  • ENSP00000491624
  • ENST00000638664
  • ENSP00000492829
  • ENST00000638712
  • ENSP00000492344
  • ENST00000638819
  • ENSP00000491334
  • ENST00000638834
  • ENSP00000492685
  • ENST00000638873
  • ENSP00000492648
  • ENST00000638940
  • ENSP00000491878
  • ENST00000639000
  • ENSP00000491947
  • ENST00000639007
  • ENSP00000492381
  • ENST00000639053
  • ENSP00000491667
  • ENST00000639257
  • ENSP00000492259
  • ENST00000639418
  • ENSP00000491050
  • ENST00000639482
  • ENSP00000491221
  • ENST00000639605
  • ENSP00000491179
  • ENST00000639607
  • ENSP00000492130
  • ENST00000639794
  • ENSP00000491103
  • ENST00000639809
  • ENSP00000491646
  • ENST00000639888
  • ENSP00000491629
  • ENST00000639895
  • ENSP00000491610
  • ENST00000639956
  • ENSP00000491098
  • ENST00000640039
  • ENSP00000491607
  • ENST00000640101
  • ENSP00000492502
  • ENST00000640104
  • ENSP00000491400
  • ENST00000640131
  • ENSP00000491666
  • ENST00000640187
  • ENSP00000492486
  • ENST00000640421
  • ENSP00000491130
  • ENST00000640463
  • ENSP00000491882
  • ENST00000640507
  • ENSP00000492445
  • ENST00000640511
  • ENSP00000491321
  • ENST00000640577
  • ENSP00000492824
  • ENST00000640717
  • ENSP00000491217
  • ENST00000640728
  • ENSP00000492383

Symbol
  • SPIN-3
  • TDRD27
  • bA445O16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
tissue sample
0.73
histone modification site profile
0.72
interacting protein
0.52
microRNA
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (23)
SPINDOC
Tdark
Novelty:  0.70981211
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.537
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.999999007
p_ni:  9.81e-7
p_wrong:  1.2e-8
Data Source:  BioPlex
NUDT1
Tchem
Family:  Enzyme
Novelty:  0.00383386
p_int:  0.999898294
p_ni:  0.000101706
Score:  0.393
Data Source:  BioPlex,STRINGDB
NDOR1
Tbio
Family:  Enzyme
Novelty:  0.07400532
p_int:  0.997878199
p_ni:  0.002121801
Data Source:  BioPlex
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.958064414
p_ni:  0.002355059
p_wrong:  0.039580527
Score:  0.161
Data Source:  BioPlex,STRINGDB
SPECC1L
Tbio
Novelty:  0.06116909
p_int:  0.952667193
p_ni:  0.047332807
Data Source:  BioPlex
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.92731662
p_ni:  0.072287957
p_wrong:  0.000395423
Data Source:  BioPlex
JMY
Tbio
Novelty:  0.01850088
p_int:  0.818782691
p_ni:  0.000125987
p_wrong:  0.181091322
Data Source:  BioPlex
GRIPAP1
Tbio
Novelty:  0.09814766
Score:  0.781
Data Source:  STRINGDB
NEXMIF
Tbio
Novelty:  0.0314095
Score:  0.722
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
3
97.2
mean platelet volume
1
1
1
87.8
platelet crit
1
1
1
85.6
balding measurement
1
1
1
83.8
heel bone mineral density
1
1
1
76
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
97.2
mean platelet volume
1
87.8
platelet crit
1
85.6
balding measurement
1
83.8
heel bone mineral density
1
76
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 5.64
PubMed score by year
PubTator Score 109.34
PubTator score by year
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Related Publications
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PMID
Year
Title