Tchem SPIN2B Spindlin-2B

Protein Summary

Description

Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).

Uniprot Accession IDs

• Q9BPZ2
• Q7Z2M0

Gene Name

• SPIN2B

Ensembl ID

• ENST00000275988
• ENSP00000275988
• ENSG00000186787
• ENST00000333933
• ENSP00000335008

Symbol

• SPIN2
• SPIN-2
• TDRD26
• SPIN-2B
• dJ323P24.2
• SPIN2_duplicate

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
histone modification site profile	0.73
cell type or tissue	0.62
tissue sample	0.56
tissue	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0