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Tchem
SPIN2B
Spindlin-2B

Protein Summary
Description
Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275988
  • ENSP00000275988
  • ENSG00000186787
  • ENST00000333933
  • ENSP00000335008

Symbol
  • SPIN2
  • SPIN-2
  • TDRD26
  • SPIN-2B
  • dJ323P24.2
  • SPIN2_duplicate
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
histone modification site profile
0.73
cell type or tissue
0.62
tissue sample
0.56
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (20)
SPIN1
Tchem
Novelty:  0.00889909
p_int:  1
Score:  0.814
Data Source:  BioPlex,STRINGDB
SPINDOC
Tdark
Novelty:  0.70981211
p_int:  1
Score:  0.795
Data Source:  BioPlex,STRINGDB
CGGBP1
Tbio
Novelty:  0.10880271
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.795
Data Source:  BioPlex,STRINGDB
ARHGAP39
Tbio
Family:  Enzyme
Novelty:  0.19918269
p_int:  0.999999786
p_ni:  1.37e-7
p_wrong:  7.7e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
XPNPEP1
Tchem
Family:  Enzyme
Novelty:  0.00345088
p_int:  0.999996273
p_ni:  0.000003727
Score:  0.246
Data Source:  BioPlex,STRINGDB
UBR7
Tbio
Family:  Epigenetic
Novelty:  0.23270052
p_int:  0.999929565
p_ni:  0.000070435
Data Source:  BioPlex
YRDC
Tdark
Novelty:  0.01240103
p_int:  0.999869996
p_ni:  0.000129998
p_wrong:  6e-9
Score:  0.735
Data Source:  BioPlex,STRINGDB
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.999569589
p_ni:  0.00042492
p_wrong:  0.000005491
Data Source:  BioPlex
FAM122B
Tdark
Novelty:  1.90668674
p_int:  0.998702669
p_ni:  0.001274493
p_wrong:  0.000022838
Data Source:  BioPlex
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.997213379
p_ni:  0.002786621
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
81.6
reticulocyte count
2
1
2
39.6
1
1
0
1.1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
81.6
reticulocyte count
2
39.6
0
1.1
4.1
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:6503238
100909485
Dog
spindlin-2B
100855689
Horse
spindlin-2B
100061997
Cow
spindlin family member 2B
100126054
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
spindlin-2B
Horse
spindlin-2B
Cow
spindlin family member 2B
Publication Statistics
PubMed Score 3.82
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title