Tchem SPIN2B Spindlin-2B

Protein Summary

Description

Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).

Uniprot Accession IDs

• Q9BPZ2
• Q7Z2M0

Gene Name

• SPIN2B

Ensembl ID

• ENST00000275988
• ENSP00000275988
• ENSG00000186787
• ENST00000333933
• ENSP00000335008

Symbol

• SPIN2
• SPIN-2
• TDRD26
• SPIN-2B
• dJ323P24.2
• SPIN2_duplicate

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
histone modification site profile	0.73
cell type or tissue	0.62
tissue sample	0.56
tissue	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

CHEMBL4451634

SPIN2BTchem

pKd : 6.95

CHEMBL4552020

SPIN2BTchem

pKd : 7.04

Protein-Protein Interactions (20)

Explore Interacting Targets

1 – 10 of 20

• See Interactions on String-DB

SPIN1

Tchem

Novelty:  0.00889909

p_int:  1

Score:  0.814

Data Source:  BioPlex,STRINGDB

SPINDOC

Tdark

Novelty:  0.70981211

p_int:  1

Score:  0.795

Data Source:  BioPlex,STRINGDB

CGGBP1

Tbio

Novelty:  0.10880271

p_int:  0.999999954

p_ni:  4.6e-8

Score:  0.795

Data Source:  BioPlex,STRINGDB

ARHGAP39

Tbio

Family:  Enzyme

Novelty:  0.19918269

p_int:  0.999999786

p_ni:  1.37e-7

p_wrong:  7.7e-8

Score:  0.214

Data Source:  BioPlex,STRINGDB

XPNPEP1

Tchem

Family:  Enzyme

Novelty:  0.00345088

p_int:  0.999996273

p_ni:  0.000003727

Score:  0.246

Data Source:  BioPlex,STRINGDB

UBR7

Tbio

Family:  Epigenetic

Novelty:  0.23270052

p_int:  0.999929565

p_ni:  0.000070435

Data Source:  BioPlex

YRDC

Tdark

Novelty:  0.01240103

p_int:  0.999869996

p_ni:  0.000129998

p_wrong:  6e-9

Score:  0.735

Data Source:  BioPlex,STRINGDB

PFDN4

Tbio

Novelty:  0.02133605

p_int:  0.999569589

p_ni:  0.00042492

p_wrong:  0.000005491

Data Source:  BioPlex

FAM122B

Tdark

Novelty:  1.90668674

p_int:  0.998702669

p_ni:  0.001274493

p_wrong:  0.000022838

Data Source:  BioPlex

PARP2

Tclin

Family:  Enzyme

Novelty:  0.00545618

p_int:  0.997213379

p_ni:  0.002786621

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (2)

Processes (4)

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1 – 1 of 1

GO Term	Evidence	Assigned by
methylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3	2	3		81.6
reticulocyte count	EFO_0007986	2	1	2		39.6
type II diabetes mellitus	EFO_0001360	1	1	0	1.1	4.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3		81.6
reticulocyte count	EFO_0007986	2		39.6
type II diabetes mellitus	EFO_0001360	0	1.1	4.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Apoptosis
Cell cycle
Complete proteome
Nucleus
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
reticulocyte count
reticulocyte measurement
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Rat	spindlin-2-like	RGD:6503238	100909485
Dog	spindlin-2B		100855689
Horse	spindlin-2B		100061997
Cow	spindlin family member 2B		100126054

Species	Name	OMA	EggNOG	Inparanoid
Rat	spindlin-2-like
Dog	spindlin-2B
Horse	spindlin-2B
Cow	spindlin family member 2B

Publication Statistics

PubMed Score 3.82

PubMed score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title