Protein Summary
Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).
- ENST00000275988
- ENSP00000275988
- ENSG00000186787
- ENST00000333933
- ENSP00000335008
- SPIN2
- SPIN-2
- TDRD26
- SPIN-2B
- dJ323P24.2
- SPIN2_duplicate
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.76 | ||
histone modification site profile | 0.73 | ||
cell type or tissue | 0.62 | ||
tissue sample | 0.56 | ||
tissue | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.82 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 69 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.82 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 69 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (20)
CGGBP1
Novelty: 0.10880271
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.795
Data Source: BioPlex,STRINGDB
ARHGAP39
Family: Enzyme
Novelty: 0.19918269
p_int: 0.999999786
p_ni: 1.37e-7
p_wrong: 7.7e-8
Score: 0.214
Data Source: BioPlex,STRINGDB
XPNPEP1
Family: Enzyme
Novelty: 0.00345088
p_int: 0.999996273
p_ni: 0.000003727
Score: 0.246
Data Source: BioPlex,STRINGDB
UBR7
Family: Epigenetic
Novelty: 0.23270052
p_int: 0.999929565
p_ni: 0.000070435
Data Source: BioPlex
YRDC
Novelty: 0.01240103
p_int: 0.999869996
p_ni: 0.000129998
p_wrong: 6e-9
Score: 0.735
Data Source: BioPlex,STRINGDB
PFDN4
Novelty: 0.02133605
p_int: 0.999569589
p_ni: 0.00042492
p_wrong: 0.000005491
Data Source: BioPlex
FAM122B
Novelty: 1.90668674
p_int: 0.998702669
p_ni: 0.001274493
p_wrong: 0.000022838
Data Source: BioPlex
PARP2
Family: Enzyme
Novelty: 0.00545618
p_int: 0.997213379
p_ni: 0.002786621
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 2 | 3 | 81.6 | |||||
reticulocyte count | 2 | 1 | 2 | 39.6 | |||||
1 | 1 | 0 | 1.1 | 4.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 81.6 | |||||
reticulocyte count | 2 | 39.6 | |||||
0 | 1.1 | 4.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Rat | RGD:6503238 | 100909485 | ||||||
Dog | spindlin-2B | 100855689 | ||||||
Horse | spindlin-2B | 100061997 | ||||||
Cow | spindlin family member 2B | 100126054 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Rat | ||||||
Dog | spindlin-2B | |||||
Horse | spindlin-2B | |||||
Cow | spindlin family member 2B | |||||
Publication Statistics
PubMed Score 3.82
PubMed score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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