Tbio SPIC Transcription factor Spi-C

Protein Summary

Description

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q8N5J4

Gene Name

• SPIC

Ensembl ID

• ENST00000551346
• ENSP00000448580
• ENSG00000166211

Symbol

• SPI-C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.93
PubMedID	0.62
biological process	0.57
cell line	0.52
virus perturbation	0.45

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Spi-c

Protein / Signaling Molecule / Transcription Factor Spi-c

Protein / Nucleic Acid Binding / Transcription Factor Spi-c

Protein / ... / Winged Helix/forkhead Transcription Factor / Transcription Factor Spi-c

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Transcription Factor Spi-c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.02   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.02   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0