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Tchem
SPHK2
Sphingosine kinase 2

Protein Summary
Description
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245222
  • ENSP00000245222
  • ENSG00000063176
  • ENST00000598088
  • ENSP00000469158
  • ENST00000599748
  • ENSP00000471205
  • ENST00000600537
  • ENSP00000470092

Symbol
  • SK 2
  • SK-2
  • SPK 2
  • SPK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
transcription factor binding site profile
0.95
transcription factor
0.82
transcription factor perturbation
0.74
kinase
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.66   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 399   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.66   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (104)
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
p_int:  0.987168536
p_ni:  0.000080397
p_wrong:  0.012751066
Score:  0.394
Data Source:  BioPlex,STRINGDB
SGPL1
Tchem
Family:  Enzyme
Novelty:  0.00272574
Score:  0.986
Data Source:  STRINGDB
SGPP1
Tbio
Family:  Enzyme
Novelty:  0.0514048
Score:  0.981
Data Source:  STRINGDB
SGPP2
Tbio
Family:  Enzyme
Novelty:  0.09408823
Score:  0.98
Data Source:  STRINGDB
ASAH2
Tbio
Family:  Enzyme
Novelty:  0.01413539
Score:  0.977
Data Source:  STRINGDB
ACER3
Tbio
Family:  Enzyme
Novelty:  0.01058501
Score:  0.966
Data Source:  STRINGDB
PLPP3
Tbio
Family:  Enzyme
Novelty:  0.01655047
Score:  0.965
Data Source:  STRINGDB
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
Score:  0.962
Data Source:  STRINGDB
ACER1
Tbio
Family:  Enzyme
Novelty:  0.05571844
Score:  0.962
Data Source:  STRINGDB
ACER2
Tchem
Family:  Enzyme
Novelty:  0.040885
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (28)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (75)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
7
6
16.2
99.6
serum gamma-glutamyl transferase measurement
3
5
4
2.3
98.9
low density lipoprotein cholesterol measurement
5
8
12
98.5
apolipoprotein B measurement
2
3
3
95.7
vitamin B12 measurement
3
3
2
70.2
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
16.2
99.6
serum gamma-glutamyl transferase measurement
4
2.3
98.9
low density lipoprotein cholesterol measurement
12
98.5
apolipoprotein B measurement
3
95.7
vitamin B12 measurement
2
70.2
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingosine kinase 2
VGNC:13534
468943
Macaque
sphingosine kinase 2
718088
Mouse
MGI:1861380
56632
Rat
RGD:1307757
308589
Dog
sphingosine kinase 2
VGNC:46737
484401
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingosine kinase 2
Macaque
sphingosine kinase 2
Mouse
Rat
Dog
sphingosine kinase 2
Publication Statistics
PubMed Score 260.66
PubMed score by year
PubTator Score 214.68
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title