Protein Summary
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
- ENST00000245222
- ENSP00000245222
- ENSG00000063176
- ENST00000598088
- ENSP00000469158
- ENST00000599748
- ENSP00000471205
- ENST00000600537
- ENSP00000470092
- SK 2
- SK-2
- SPK 2
- SPK-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
transcription factor binding site profile | 0.95 | ||
transcription factor | 0.82 | ||
transcription factor perturbation | 0.74 | ||
kinase | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 260.66 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 399 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 260.66 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 399 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (13)
Protein-Protein Interactions (104)
RAB9A
Family: Enzyme
Novelty: 0.07006531
p_int: 0.987168536
p_ni: 0.000080397
p_wrong: 0.012751066
Score: 0.394
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (3)
Downstream (1)
1 – 3 of 3
Pathways (28)
Reactome (4)
KEGG (9)
PathwayCommons (6)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Sphingolipid de novo biosynthesis | ||||
Reactome | Sphingolipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of lipids | ||||
Sphingolipid de novo biosynthesis | ||||
Sphingolipid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (6)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (75)
Items per page:
1 – 5 of 75
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 4 | 7 | 6 | 16.2 | 99.6 | ||||
serum gamma-glutamyl transferase measurement | 3 | 5 | 4 | 2.3 | 98.9 | ||||
low density lipoprotein cholesterol measurement | 5 | 8 | 12 | 98.5 | |||||
apolipoprotein B measurement | 2 | 3 | 3 | 95.7 | |||||
vitamin B12 measurement | 3 | 3 | 2 | 70.2 | 93.8 | ||||
Items per page:
1 – 5 of 75
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 6 | 16.2 | 99.6 | ||||
serum gamma-glutamyl transferase measurement | 4 | 2.3 | 98.9 | ||||
low density lipoprotein cholesterol measurement | 12 | 98.5 | |||||
apolipoprotein B measurement | 3 | 95.7 | |||||
vitamin B12 measurement | 2 | 70.2 | 93.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sphingosine kinase 2 | VGNC:13534 | 468943 | |||||
Macaque | sphingosine kinase 2 | 718088 | ||||||
Mouse | MGI:1861380 | 56632 | ||||||
Rat | RGD:1307757 | 308589 | ||||||
Dog | sphingosine kinase 2 | VGNC:46737 | 484401 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sphingosine kinase 2 | |||||
Macaque | sphingosine kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sphingosine kinase 2 | |||||
Publication Statistics
PubMed Score 260.66
PubMed score by year
PubTator Score 214.68
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (73)
GeneRif Annotations (56)
Items per page:
0 of 0
PMID | Year | Title |
|---|