Protein Summary
ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735). This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2014]
- ENST00000341316
- ENSP00000341157
- ENSG00000197912
- ENST00000645818
- ENSP00000495795
- ENST00000646263
- ENSP00000494119
- CAR
- CMAR
- PGN
- CAR
- PGN
- CMAR
- SPG5C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 1 | ||
molecular function | 0.96 | ||
transcription factor binding site profile | 0.91 | ||
transcription factor perturbation | 0.88 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 298.89 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 330 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 298.89 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 330 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (217)
NDUFB9
Family: Enzyme
Novelty: 0.00715628
p_int: 0.996819252
p_ni: 0.003175909
p_wrong: 0.000004839
Score: 0.241
Data Source: BioPlex,STRINGDB
LPAR4
Family: GPCR
Novelty: 0.02200758
p_int: 0.992807012
p_ni: 0.007192987
Data Source: BioPlex
LPCAT4
Family: Enzyme
Novelty: 0.246654
p_int: 0.991863423
p_ni: 0.008136577
Score: 0.212
Data Source: BioPlex,STRINGDB
PHETA1
Novelty: 0.52415295
p_int: 0.947207147
p_ni: 0.052792853
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
CPA5
Family: Enzyme
Novelty: 0.0516555
p_int: 0.878983469
p_ni: 0.121016512
p_wrong: 1.9e-8
Score: 0.215
Data Source: BioPlex,STRINGDB
FAM174A
Novelty: 0.30693139
p_int: 0.873509477
p_ni: 0.126490509
p_wrong: 1.3e-8
Data Source: BioPlex
HDAC10
Family: Epigenetic
Novelty: 0.00976829
p_int: 0.864235519
p_ni: 0.135762501
p_wrong: 0.00000198
Score: 0.195
Data Source: BioPlex,STRINGDB
CD79A
Novelty: 0.00118942
p_int: 0.808052759
p_ni: 0.191947212
p_wrong: 2.8e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Mitochondrial calcium ion transport | ||||
Reactome | Processing of SMDT1 | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Mitochondrial calcium ion transport | ||||
Processing of SMDT1 | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (5)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
suntan | 1 | 4 | 4 | 98.9 | |||||
hair color | 1 | 2 | 0 | 6.4 | 92.9 | ||||
homocysteine measurement | 2 | 2 | 2 | 92.3 | |||||
glomerular filtration rate | 5 | 4 | 5 | 92 | |||||
1 | 1 | 1 | 86 | ||||||
Items per page:
1 – 5 of 36
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
suntan | 4 | 98.9 | |||||
hair color | 0 | 6.4 | 92.9 | ||||
homocysteine measurement | 2 | 92.3 | |||||
glomerular filtration rate | 5 | 92 | |||||
1 | 86 | ||||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | SPG7, paraplegin matrix AAA peptidase subunit | VGNC:14497 | 737127 | |||||
Mouse | MGI:2385906 | 234847 | ||||||
Rat | RGD:727940 | 353231 | ||||||
Dog | SPG7, paraplegin matrix AAA peptidase subunit | VGNC:46736 | 489657 | |||||
Horse | SPG7, paraplegin matrix AAA peptidase subunit | VGNC:51329 | 100051955 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | SPG7, paraplegin matrix AAA peptidase subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | SPG7, paraplegin matrix AAA peptidase subunit | |||||
Horse | SPG7, paraplegin matrix AAA peptidase subunit | |||||
Publication Statistics
PubMed Score 298.89
PubMed score by year
PubTator Score 151.62
PubTator score by year
Related Publications
Text Mined References (50)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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