You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SPEM1
Spermatid maturation protein 1

Protein Summary
Description
Required for proper cytoplasm removal during spermatogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323675
  • ENSP00000315554
  • ENSG00000181323
  • ENST00000640564
  • ENSP00000492561
  • ENSG00000284598

Symbol
  • C17orf83
  • C17orf83
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.6
gene perturbation
0.5
cell type or tissue
0.49
tissue
0.42
cellular component
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
PPP1R1A
Tbio
Family:  Enzyme
Novelty:  0.01565981
p_int:  0.999993648
p_ni:  0.000006348
p_wrong:  4e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.960710514
p_ni:  0.000040011
p_wrong:  0.039249476
Score:  0.188
Data Source:  BioPlex,STRINGDB
HOOK1
Tbio
Novelty:  0.04136856
Score:  0.753
Data Source:  STRINGDB
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
Score:  0.71
Data Source:  STRINGDB
TNP1
Tbio
Novelty:  0.01264731
Score:  0.689
Data Source:  STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
Score:  0.675
Data Source:  STRINGDB
SPATA3
Tdark
Novelty:  0.19208899
Score:  0.668
Data Source:  STRINGDB
ZMYND15
Tdark
Novelty:  0.27241886
Score:  0.65
Data Source:  STRINGDB
UBQLN1
Tbio
Novelty:  0.00921991
Score:  0.643
Data Source:  STRINGDB
SPERT
Tbio
Novelty:  0.12255061
Score:  0.634
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (64)
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
12
12
1.3
99.1
testosterone measurement
3
12
12
1.3
99.1
appendicular lean mass
3
3
5
94.4
appendicular lean mass
3
3
5
94.4
body height
2
2
2
91.4
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
12
1.3
99.1
testosterone measurement
12
1.3
99.1
appendicular lean mass
5
94.4
appendicular lean mass
5
94.4
body height
2
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spermatid maturation 1
VGNC:9649
100614626
Macaque
spermatid maturation 1
715371
Mouse
MGI:1921538
74288
Rat
RGD:1593311
691981
Horse
spermatid maturation 1 [Source:HGNC Symbol;Acc:HGNC:32429]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spermatid maturation 1
Macaque
spermatid maturation 1
Mouse
Rat
Horse
spermatid maturation 1 [Source:HGNC Symbol;Acc:HGNC:32429]
Publication Statistics
PubMed Score 4.56
PubMed score by year
PubTator Score 1.63
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title