Tbio SPEF2 Sperm flagellar protein 2

Protein Summary

Description

Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.

Uniprot Accession IDs

• Q9C093
• Q2TAC9
• Q96LL6
• Q9H5C7
• Q9H5Q7

Gene Name

• SPEF2

Ensembl ID

• ENST00000282469
• ENSP00000282469
• ENSG00000152582
• ENST00000356031
• ENSP00000348314
• ENST00000440995
• ENSP00000412125

Symbol

• KIAA1770
• KPL2
• KPL2
• CT122

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
cell type or tissue	0.81
cell line	0.64
phenotype	0.62
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.51   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.51   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0