Tdark SPEF1 Sperm flagellar protein 1

Protein Summary

Description

Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity).

Uniprot Accession IDs

• Q9Y4P9
• A5YM71
• D3DVY0
• Q5JX78

Gene Name

• SPEF1

Ensembl ID

• ENST00000379756
• ENSP00000369080
• ENSG00000101222

Symbol

• C20orf28
• CLAMP
• SPEF1A
• C20orf28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.91
virus perturbation	0.83
cell type or tissue	0.61
cellular component	0.55
transcription factor binding site profile	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.87   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 21   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.87   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0