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Tbio
SPECC1
Cytospin-B

Protein Summary
Description
The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261503
  • ENSP00000261503
  • ENSG00000128487
  • ENST00000395522
  • ENSP00000378893
  • ENST00000395525
  • ENSP00000378896
  • ENST00000395527
  • ENSP00000378898
  • ENST00000395529
  • ENSP00000378900
  • ENST00000395530
  • ENSP00000378901

Symbol
  • CYTSB
  • NSP5
  • NSP
  • CYTSB
  • HCMOGT1
  • HCMOGT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor perturbation
0.88
transcription factor binding site profile
0.82
transcription factor
0.74
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
RAB11FIP4
Tbio
Novelty:  0.13545871
p_int:  0.999999158
p_ni:  3.75e-7
p_wrong:  4.68e-7
Score:  0.311
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.999957102
p_ni:  0.000042895
p_wrong:  3e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
PCDHB11
Tdark
Novelty:  0.80480462
p_int:  0.999890174
p_ni:  0.000109741
p_wrong:  8.5e-8
Score:  0.197
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999768286
p_ni:  0.000230387
p_wrong:  0.000001328
Data Source:  BioPlex
PCDHA8
Tdark
Novelty:  0.57189179
p_int:  0.999583663
p_ni:  0.000414392
p_wrong:  0.000001945
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.99956779
p_ni:  0.000311482
p_wrong:  0.000120727
Data Source:  BioPlex
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.993909883
p_ni:  0.005730785
p_wrong:  0.000359332
Data Source:  BioPlex
PRSS57
Tbio
Family:  Enzyme
Novelty:  0.00250647
Score:  0.922
Data Source:  STRINGDB
SH2D3A
Tbio
Novelty:  0.00185943
Score:  0.921
Data Source:  STRINGDB
SH2D3C
Tbio
Novelty:  0.00356605
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
3
3
96.5
reticulocyte count
7
4
7
94.1
mean reticulocyte volume
1
2
2
92.1
reticulocyte measurement
3
2
3
89.5
mean corpuscular hemoglobin concentration
1
1
1
87.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
96.5
reticulocyte count
7
94.1
mean reticulocyte volume
2
92.1
reticulocyte measurement
3
89.5
mean corpuscular hemoglobin concentration
1
87.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm antigen with calponin homology and coiled-coil domains 1
VGNC:12690
741463
Macaque
sperm antigen with calponin homology and coiled-coil domains 1
704221
Mouse
MGI:2442356
432572
Rat
RGD:1309718
303208
Dog
sperm antigen with calponin homology and coiled-coil domains 1
VGNC:46729
489524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm antigen with calponin homology and coiled-coil domains 1
Macaque
sperm antigen with calponin homology and coiled-coil domains 1
Mouse
Rat
Dog
sperm antigen with calponin homology and coiled-coil domains 1
Publication Statistics
PubMed Score 125.16
PubMed score by year
PubTator Score 320.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title