Protein Summary
The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
- ENST00000261503
- ENSP00000261503
- ENSG00000128487
- ENST00000395522
- ENSP00000378893
- ENST00000395525
- ENSP00000378896
- ENST00000395527
- ENSP00000378898
- ENST00000395529
- ENSP00000378900
- ENST00000395530
- ENSP00000378901
- CYTSB
- NSP5
- NSP
- CYTSB
- HCMOGT1
- HCMOGT-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.82 | ||
transcription factor | 0.74 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.16 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 205 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.16 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 205 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (42)
RAB11FIP4
Novelty: 0.13545871
p_int: 0.999999158
p_ni: 3.75e-7
p_wrong: 4.68e-7
Score: 0.311
Data Source: BioPlex,STRINGDB
PCDHGB1
Novelty: 0.60440805
p_int: 0.999957102
p_ni: 0.000042895
p_wrong: 3e-9
Score: 0.154
Data Source: BioPlex,STRINGDB
PCDHB11
Novelty: 0.80480462
p_int: 0.999890174
p_ni: 0.000109741
p_wrong: 8.5e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
NUP62
Novelty: 0.01432724
p_int: 0.999768286
p_ni: 0.000230387
p_wrong: 0.000001328
Data Source: BioPlex
PCDHA8
Novelty: 0.57189179
p_int: 0.999583663
p_ni: 0.000414392
p_wrong: 0.000001945
Data Source: BioPlex
SLC25A41
Family: Transporter
Novelty: 1.04918395
p_int: 0.99956779
p_ni: 0.000311482
p_wrong: 0.000120727
Data Source: BioPlex
PCDHGB2
Novelty: 1.16587709
p_int: 0.993909883
p_ni: 0.005730785
p_wrong: 0.000359332
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 3 | 3 | 96.5 | |||||
reticulocyte count | 7 | 4 | 7 | 94.1 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 92.1 | |||||
reticulocyte measurement | 3 | 2 | 3 | 89.5 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 87.7 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 3 | 96.5 | |||||
reticulocyte count | 7 | 94.1 | |||||
mean reticulocyte volume | 2 | 92.1 | |||||
reticulocyte measurement | 3 | 89.5 | |||||
mean corpuscular hemoglobin concentration | 1 | 87.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sperm antigen with calponin homology and coiled-coil domains 1 | VGNC:12690 | 741463 | |||||
Macaque | sperm antigen with calponin homology and coiled-coil domains 1 | 704221 | ||||||
Mouse | MGI:2442356 | 432572 | ||||||
Rat | RGD:1309718 | 303208 | ||||||
Dog | sperm antigen with calponin homology and coiled-coil domains 1 | VGNC:46729 | 489524 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sperm antigen with calponin homology and coiled-coil domains 1 | |||||
Macaque | sperm antigen with calponin homology and coiled-coil domains 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sperm antigen with calponin homology and coiled-coil domains 1 | |||||
Publication Statistics
PubMed Score 125.16
PubMed score by year
PubTator Score 320.38
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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