Tbio SPDL1 Protein Spindly

Protein Summary

Description

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q96EA4
• B4E393
• C9JS47
• Q8TEC8
• Q9HD44
• Q9NX97
• hSpindly

Gene Name

• SPDL1

Ensembl ID

• ENST00000265295
• ENSP00000265295
• ENSG00000040275

Symbol

• CCDC99
• CCDC99

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
histone modification site profile	0.74
transcription factor binding site profile	0.63
transcription factor perturbation	0.54
cellular component	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.21   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.21   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (218)

Explore Interacting Targets

1 – 10 of 218

• See Interactions on String-DB

FNTB

Tclin

Family:  Enzyme

Novelty:  0.07434994

p_int:  0.999998719

p_ni:  0.000001281

Data Source:  BioPlex

GSTT2B

Tbio

Family:  Enzyme

Novelty:  0.02334158

p_int:  0.999998319

p_ni:  0.000001681

Score:  0.187

Data Source:  BioPlex,STRINGDB

HAUS7

Tbio

Novelty:  1.11657571

p_int:  0.999982229

p_ni:  0.000017771

Data Source:  BioPlex

SEC13

Tbio

Novelty:  0.00709413

p_int:  0.999885965

p_ni:  0.000114035

Score:  0.912

Data Source:  BioPlex,STRINGDB

TXLNB

Tbio

Novelty:  0.12751933

p_int:  0.999741033

p_ni:  0.000258967

Score:  0.177

Data Source:  BioPlex,STRINGDB

BFSP1

Tbio

Novelty:  0.01519136

p_int:  0.997935741

p_ni:  0.002064253

p_wrong:  6e-9

Data Source:  BioPlex

FNTA

Tclin

Family:  Enzyme

Novelty:  0.03163169

p_int:  0.997794984

p_ni:  0.002205007

p_wrong:  9e-9

Data Source:  BioPlex

NFKBIA

Tchem

Novelty:  0.00022873

p_int:  0.996429686

p_ni:  0.00357026

p_wrong:  5.4e-8

Data Source:  BioPlex

PMEL

Tbio

Novelty:  0.00116525

p_int:  0.995765595

p_ni:  0.004234393

p_wrong:  1.1e-8

Data Source:  BioPlex

THUMPD2

Tdark

Novelty:  0.66682546

p_int:  0.995631532

p_ni:  0.00436839

p_wrong:  7.8e-8

Score:  0.309

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (16)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (5)

Processes (5)

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1 – 2 of 2

GO Term	Evidence	Assigned by
kinetochore binding	Inferred from Direct Assay (IDA)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	4	1	4		74.5
self reported educational attainment	EFO_0004784	1	1	1		5.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	4		74.5
self reported educational attainment	EFO_0004784	1		5.6

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
self reported educational attainment
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	spindle apparatus coiled-coil protein 1	VGNC:4173	462255
Macaque	spindle apparatus coiled-coil protein 1		699624
Mouse	spindle apparatus coiled-coil protein 1	MGI:1917635	70385
Rat	spindle apparatus coiled-coil protein 1	RGD:1306908	303037
Dog	spindle apparatus coiled-coil protein 1	VGNC:46727	479295

Species	Name	OMA	EggNOG	Inparanoid
Chimp	spindle apparatus coiled-coil protein 1
Macaque	spindle apparatus coiled-coil protein 1
Mouse	spindle apparatus coiled-coil protein 1
Rat	spindle apparatus coiled-coil protein 1
Dog	spindle apparatus coiled-coil protein 1

Publication Statistics

PubMed Score 104.21

PubMed score by year

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PubTator Score 9.91

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (5)

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PMID	Year	Title