Protein Summary
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). This gene encodes a coiled-coil domain-containing protein that functions in mitot ...more
- ENST00000265295
- ENSP00000265295
- ENSG00000040275
- CCDC99
- CCDC99
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
ligand (protein) perturbation | 0.83 | ||
histone modification site profile | 0.74 | ||
transcription factor binding site profile | 0.63 | ||
transcription factor perturbation | 0.54 | ||
cellular component | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 104.21 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 199 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 104.21 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 199 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (218)
FNTB
Family: Enzyme
Novelty: 0.07434994
p_int: 0.999998719
p_ni: 0.000001281
Data Source: BioPlex
GSTT2B
Family: Enzyme
Novelty: 0.02334158
p_int: 0.999998319
p_ni: 0.000001681
Score: 0.187
Data Source: BioPlex,STRINGDB
SEC13
Novelty: 0.00709413
p_int: 0.999885965
p_ni: 0.000114035
Score: 0.912
Data Source: BioPlex,STRINGDB
TXLNB
Novelty: 0.12751933
p_int: 0.999741033
p_ni: 0.000258967
Score: 0.177
Data Source: BioPlex,STRINGDB
BFSP1
Novelty: 0.01519136
p_int: 0.997935741
p_ni: 0.002064253
p_wrong: 6e-9
Data Source: BioPlex
FNTA
Family: Enzyme
Novelty: 0.03163169
p_int: 0.997794984
p_ni: 0.002205007
p_wrong: 9e-9
Data Source: BioPlex
NFKBIA
Novelty: 0.00022873
p_int: 0.996429686
p_ni: 0.00357026
p_wrong: 5.4e-8
Data Source: BioPlex
PMEL
Novelty: 0.00116525
p_int: 0.995765595
p_ni: 0.004234393
p_wrong: 1.1e-8
Data Source: BioPlex
THUMPD2
Novelty: 0.66682546
p_int: 0.995631532
p_ni: 0.00436839
p_wrong: 7.8e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 1 | 4 | 74.5 | |||||
self reported educational attainment | 1 | 1 | 1 | 5.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 74.5 | |||||
self reported educational attainment | 1 | 5.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | spindle apparatus coiled-coil protein 1 | VGNC:4173 | 462255 | |||||
Macaque | spindle apparatus coiled-coil protein 1 | 699624 | ||||||
Mouse | MGI:1917635 | 70385 | ||||||
Rat | RGD:1306908 | 303037 | ||||||
Dog | spindle apparatus coiled-coil protein 1 | VGNC:46727 | 479295 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | spindle apparatus coiled-coil protein 1 | |||||
Macaque | spindle apparatus coiled-coil protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | spindle apparatus coiled-coil protein 1 | |||||
Publication Statistics
PubMed Score 104.21
PubMed score by year
PubTator Score 9.91
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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