Tbio SPDEF SAM pointed domain-containing Ets transcription factor

Protein Summary

Description

May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• O95238
• B4DWH8
• F5H778

Gene Name

• SPDEF

Ensembl ID

• ENST00000374037
• ENSP00000363149
• ENSG00000124664
• ENST00000544425
• ENSP00000442715

Symbol

• PDEF
• PSE
• PDEF
• bA375E1.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.81
small molecule perturbation	0.73
virus perturbation	0.68
tissue sample	0.67
cell type or tissue	0.62

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Sam Pointed Domain-containing Ets Transcription Factor

Protein / Signaling Molecule / Sam Pointed Domain-containing Ets Transcription Factor

Protein / Nucleic Acid Binding / Sam Pointed Domain-containing Ets Transcription Factor

Protein / ... / Winged Helix/forkhead Transcription Factor / Sam Pointed Domain-containing Ets Transcription Factor

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Sam Pointed Domain-containing Ets Transcription Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.52   (req: < 5)

Gene RIFs: 58   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.52   (req: >= 5)

Gene RIFs: 58   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0