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Tbio
SPDEF
SAM pointed domain-containing Ets transcription factor

Protein Summary
Description
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374037
  • ENSP00000363149
  • ENSG00000124664
  • ENST00000544425
  • ENSP00000442715

Symbol
  • PDEF
  • PSE
  • PDEF
  • bA375E1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.81
small molecule perturbation
0.73
virus perturbation
0.68
tissue sample
0.67
cell type or tissue
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.7   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.7   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
PRDM16
Tbio
Family:  TF; Epigenetic
Novelty:  0.00261891
p_int:  0.999999988
p_wrong:  1.2e-8
Score:  0.544
Data Source:  BioPlex,STRINGDB
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.999999759
p_ni:  2.41e-7
Score:  0.267
Data Source:  BioPlex,STRINGDB
C5orf30
Tdark
Novelty:  0.2072045
p_int:  0.999990514
p_ni:  0.000009478
p_wrong:  9e-9
Score:  0.834
Data Source:  BioPlex,STRINGDB
MYO5C
Tbio
Novelty:  0.05680943
p_int:  0.993300155
p_ni:  0.006699845
Score:  0.282
Data Source:  BioPlex,STRINGDB
FASTKD1
Tbio
Family:  Enzyme
Novelty:  0.64864074
p_int:  0.893167017
p_ni:  0.106832983
Score:  0.204
Data Source:  BioPlex,STRINGDB
SLC4A2
Tbio
Family:  Transporter
Novelty:  0.02448062
p_int:  0.881970772
p_ni:  0.118029228
Score:  0.181
Data Source:  BioPlex,STRINGDB
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.835334976
p_ni:  0.164665024
Score:  0.192
Data Source:  BioPlex,STRINGDB
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.798273642
p_ni:  0.201726358
Score:  0.546
Data Source:  BioPlex,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.804
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.802
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
PDGF signaling pathway
PathwayCommons: pid
Regulation of Androgen receptor activity
PathwayCommons: netpath
AndrogenReceptor
Name
Explore in Pharos
Explore in Source
PDGF signaling pathway
Regulation of Androgen receptor activity
AndrogenReceptor
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
11
11
96.2
body mass index
9
4
12
95.2
high density lipoprotein cholesterol measurement
1
1
1
83
apolipoprotein A 1 measurement
1
1
1
81.2
low density lipoprotein cholesterol measurement
2
2
2
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
11
96.2
body mass index
12
95.2
high density lipoprotein cholesterol measurement
1
83
apolipoprotein A 1 measurement
1
81.2
low density lipoprotein cholesterol measurement
2
80.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SAM pointed domain containing ETS transcription factor
VGNC:3710
462627
Mouse
MGI:1353422
30051
Rat
RGD:1594842
689210
Dog
SAM pointed domain containing ETS transcription factor
VGNC:46726
481751
Horse
SAM pointed domain containing ETS transcription factor
VGNC:23508
100053106
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SAM pointed domain containing ETS transcription factor
Mouse
Rat
Dog
SAM pointed domain containing ETS transcription factor
Horse
SAM pointed domain containing ETS transcription factor
Publication Statistics
PubMed Score 181.70
PubMed score by year
PubTator Score 69.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title