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Tbio
SPC24
Kinetochore protein Spc24

Protein Summary
Description
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000592540
  • ENSP00000465075
  • ENSG00000161888

Symbol
  • SPBC24
  • SPBC24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.72
cellular component
0.69
tissue sample
0.62
transcription factor
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.54   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.54   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
SPC25
Tbio
Novelty:  0.26354244
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NSL1
Tbio
Novelty:  0.01396984
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
DSN1
Tbio
Novelty:  0.05336903
p_int:  0.999999999
p_ni:  1e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999999927
p_ni:  7.3e-8
Score:  0.458
Data Source:  BioPlex,Reactome,STRINGDB
NDC80
Tbio
Novelty:  0.00331814
p_int:  0.999999816
p_ni:  1.84e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NUF2
Tbio
Novelty:  0.01069726
p_int:  0.999999767
p_ni:  2.33e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MIS12
Tbio
Novelty:  0.05345698
p_int:  0.999998465
p_ni:  0.000001535
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
KNL1
Tbio
Novelty:  0.01084826
p_int:  0.999993154
p_ni:  0.000006846
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.999918493
p_ni:  0.000081507
Score:  0.997
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.998393086
p_ni:  0.001606914
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
22
50
67
4.6
100
total cholesterol measurement
18
44
55
4.3
100
apolipoprotein B measurement
2
26
26
100
reticulocyte count
7
6
11
99.3
reticulocyte measurement
3
6
8
99.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
67
4.6
100
total cholesterol measurement
55
4.3
100
apolipoprotein B measurement
26
100
reticulocyte count
11
99.3
reticulocyte measurement
8
99.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPC24, NDC80 kinetochore complex component
VGNC:13535
746242
Macaque
SPC24, NDC80 kinetochore complex component
714043
Mouse
MGI:1914879
67629
Rat
RGD:1307631
363028
Dog
SPC24, NDC80 kinetochore complex component
VGNC:46723
611174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPC24, NDC80 kinetochore complex component
Macaque
SPC24, NDC80 kinetochore complex component
Mouse
Rat
Dog
SPC24, NDC80 kinetochore complex component
Publication Statistics
PubMed Score 30.54
PubMed score by year
PubTator Score 7.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title