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Tdark
SPATA24
Spermatogenesis-associated protein 24

Protein Summary
Description
Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450845
  • ENSP00000414920
  • ENSG00000170469
  • ENST00000451821
  • ENSP00000400524

Symbol
  • T6441
  • CCDC161
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
tissue sample
0.7
transcription factor perturbation
0.61
tissue
0.6
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.87   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.87   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
DCAF17
Tbio
Novelty:  0.04261326
p_int:  0.999999908
p_ni:  9.1e-8
p_wrong:  1e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
CEP72
Tbio
Novelty:  0.06830459
p_int:  0.999993177
p_ni:  2.47e-7
p_wrong:  0.000006576
Score:  0.193
Data Source:  BioPlex,STRINGDB
STXBP2
Tbio
Novelty:  0.01896992
p_int:  0.999966015
p_ni:  0.000033985
Score:  0.165
Data Source:  BioPlex,STRINGDB
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.998741682
p_ni:  0.001258318
Data Source:  BioPlex
TRIM9
Tbio
Family:  Enzyme
Novelty:  0.06250762
p_int:  0.996225464
p_ni:  0.000558889
p_wrong:  0.003215647
Score:  0.19
Data Source:  BioPlex,STRINGDB
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.991588098
p_ni:  1.54e-7
p_wrong:  0.008411747
Data Source:  BioPlex
GRPEL1
Tbio
Novelty:  0.00185346
p_int:  0.989800321
p_ni:  0.010199679
Score:  0.19
Data Source:  BioPlex,STRINGDB
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.961056787
p_ni:  0.038943213
Data Source:  BioPlex
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.951832696
p_ni:  0.048166635
p_wrong:  6.69e-7
Data Source:  BioPlex
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.946624326
p_ni:  0.049994281
p_wrong:  0.003381393
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
1
1
86.9
1
1
0
1.2
72.1
viral load
1
1
1
66.8
electrocardiography
1
1
4
62.1
reticulocyte count
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin C measurement
1
86.9
0
1.2
72.1
viral load
1
66.8
electrocardiography
4
62.1
reticulocyte count
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spermatogenesis associated 24
VGNC:4177
746585
Mouse
MGI:1918492
71242
Rat
RGD:1311742
291676
Dog
spermatogenesis associated 24
VGNC:46711
612738
Horse
spermatogenesis associated 24
VGNC:23489
100062113
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spermatogenesis associated 24
Mouse
Rat
Dog
spermatogenesis associated 24
Horse
spermatogenesis associated 24
Publication Statistics
PubMed Score 0.87
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title