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Tbio
SPATA2
Spermatogenesis-associated protein 2

Protein Summary
Description
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289431
  • ENSP00000289431
  • ENSG00000158480
  • ENST00000422556
  • ENSP00000416799

Symbol
  • KIAA0757
  • PD1
  • PD1
  • tamo
  • PPP1R145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
microRNA
0.81
transcription factor binding site profile
0.74
tissue sample
0.72
phenotype
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.18   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.18   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
FGL2
Tbio
Novelty:  0.01108434
p_int:  0.999999214
p_ni:  2.9e-8
p_wrong:  7.57e-7
Score:  0.527
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999997135
p_ni:  0.000002849
p_wrong:  1.6e-8
Data Source:  BioPlex
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
p_int:  0.999757683
p_ni:  0.000242317
Score:  0.552
Data Source:  BioPlex,STRINGDB
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.993877704
p_ni:  0.006122281
p_wrong:  1.6e-8
Data Source:  BioPlex
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.986906577
p_ni:  0.013093422
p_wrong:  2e-9
Data Source:  BioPlex
PM20D2
Tdark
Family:  Enzyme
Novelty:  0.63491472
p_int:  0.932552552
p_ni:  0.067447448
Data Source:  BioPlex
DLG1
Tbio
Novelty:  0.0050926
p_int:  0.879192069
p_ni:  0.120807931
Data Source:  BioPlex
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
Score:  0.968
Data Source:  STRINGDB
CYLD
Tbio
Family:  Enzyme
Novelty:  0.00215465
Score:  0.961
Data Source:  STRINGDB
SHARPIN
Tbio
Novelty:  0.0197352
Score:  0.897
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
73.4
psoriasis vulgaris
1
1
0
1.2
54.4
2
2
0
1.1
17.6
gut microbiome measurement
1
1
1
14.2
1
1
0
2.1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
73.4
psoriasis vulgaris
0
1.2
54.4
0
1.1
17.6
gut microbiome measurement
1
14.2
0
2.1
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spermatogenesis associated 2
VGNC:6271
458327
Macaque
spermatogenesis associated 2
702817
Mouse
MGI:2146885
263876
Rat
RGD:620754
114210
Dog
spermatogenesis associated 2
VGNC:46708
485923
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spermatogenesis associated 2
Macaque
spermatogenesis associated 2
Mouse
Rat
Dog
spermatogenesis associated 2
Publication Statistics
PubMed Score 12.18
PubMed score by year
PubTator Score 9.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title