Tbio SPATA2 Spermatogenesis-associated protein 2

Protein Summary

Description

Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).

Uniprot Accession IDs

• Q9UM82
• E1P626
• O94857

Gene Name

• SPATA2

Ensembl ID

• ENST00000289431
• ENSP00000289431
• ENSG00000158480
• ENST00000422556
• ENSP00000416799

Symbol

• KIAA0757
• PD1
• PD1
• tamo
• PPP1R145

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
microRNA	0.81
transcription factor binding site profile	0.74
tissue sample	0.72
phenotype	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.18   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.18   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (29)

Explore Interacting Targets

1 – 10 of 29

• See Interactions on String-DB

FGL2

Tbio

Novelty:  0.01108434

p_int:  0.999999214

p_ni:  2.9e-8

p_wrong:  7.57e-7

Score:  0.527

Data Source:  BioPlex,STRINGDB

MID1IP1

Tbio

Novelty:  0.11443752

p_int:  0.999997135

p_ni:  0.000002849

p_wrong:  1.6e-8

Data Source:  BioPlex

CASK

Tchem

Family:  Kinase

Novelty:  0.00856437

p_int:  0.999757683

p_ni:  0.000242317

Score:  0.552

Data Source:  BioPlex,STRINGDB

SNX6

Tbio

Novelty:  0.05909848

p_int:  0.993877704

p_ni:  0.006122281

p_wrong:  1.6e-8

Data Source:  BioPlex

SNX2

Tbio

Novelty:  0.03880384

p_int:  0.986906577

p_ni:  0.013093422

p_wrong:  2e-9

Data Source:  BioPlex

PM20D2

Tdark

Family:  Enzyme

Novelty:  0.63491472

p_int:  0.932552552

p_ni:  0.067447448

Data Source:  BioPlex

DLG1

Tbio

Novelty:  0.0050926

p_int:  0.879192069

p_ni:  0.120807931

Data Source:  BioPlex

RNF31

Tbio

Family:  Enzyme

Novelty:  0.01394304

Score:  0.968

Data Source:  STRINGDB

CYLD

Tbio

Family:  Enzyme

Novelty:  0.00215465

Score:  0.961

Data Source:  STRINGDB

SHARPIN

Tbio

Novelty:  0.0197352

Score:  0.897

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Necroptosis	151 targets	path:hsa04217

Name	Explore in Pharos	Explore in Source
Necroptosis	151 targets	path:hsa04217

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Components (3)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
fibrillar center	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	HPA

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriasis	EFO_0000676	3	2	0	1.2	73.4
psoriasis vulgaris	EFO_1001494	1	1	0	1.2	54.4
multiple sclerosis	EFO_0003885	2	2	0	1.1	17.6
gut microbiome measurement	EFO_0007874	1	1	1		14.2
systemic lupus erythematosus	EFO_0002690	1	1	0	2.1	12.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
psoriasis	EFO_0000676	0	1.2	73.4
psoriasis vulgaris	EFO_1001494	0	1.2	54.4
multiple sclerosis	EFO_0003885	0	1.1	17.6
gut microbiome measurement	EFO_0007874	1		14.2
systemic lupus erythematosus	EFO_0002690	0	2.1	12.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Cytoplasm
Developmental protein
Necrosis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
gut microbiome measurement
multiple sclerosis
psoriasis
psoriasis vulgaris
systemic lupus erythematosus

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
immune system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	spermatogenesis associated 2	VGNC:6271	458327
Macaque	spermatogenesis associated 2		702817
Mouse	spermatogenesis associated 2	MGI:2146885	263876
Rat	spermatogenesis associated 2	RGD:620754	114210
Dog	spermatogenesis associated 2	VGNC:46708	485923

Species	Name	OMA	EggNOG	Inparanoid
Chimp	spermatogenesis associated 2
Macaque	spermatogenesis associated 2
Mouse	spermatogenesis associated 2
Rat	spermatogenesis associated 2
Dog	spermatogenesis associated 2

Publication Statistics

PubMed Score 12.18

PubMed score by year

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PubTator Score 9.11

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (10)

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10

0 of 0

PMID	Year	Title