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Tbio
SPATA13
Spermatogenesis-associated protein 13

Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343003
  • ENSP00000343631
  • ENSG00000182957
  • ENST00000382095
  • ENSP00000371527
  • ENST00000382108
  • ENSP00000371542
  • ENST00000399949
  • ENSP00000382830
  • ENST00000424834
  • ENSP00000398560

Symbol
  • ASEF2
  • ARHGEF29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
trait
0.75
virus perturbation
0.72
tissue sample
0.68
phenotype
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0