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Tbio
SPAST
Spastin

Protein Summary
Description
ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315285
  • ENSP00000320885
  • ENSG00000021574
  • ENST00000345662
  • ENSP00000340817
  • ENST00000615843
  • ENSP00000480893
  • ENST00000642999
  • ENSP00000496589
  • ENST00000644954
  • ENSP00000494312
  • ENST00000646571
  • ENSP00000495015

Symbol
  • ADPSP
  • FSP2
  • KIAA1083
  • SPG4
  • FSP2
  • SPG4
  • ADPSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.89
biological term
0.87
protein domain
0.85
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.71   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.71   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
IST1
Tbio
Novelty:  0.01780503
p_int:  0.999999034
p_ni:  7.74e-7
p_wrong:  1.92e-7
Score:  0.803
Data Source:  BioPlex,STRINGDB
NUP98
Tbio
Family:  Enzyme
Novelty:  0.00401452
p_int:  0.997468454
p_ni:  0.002531546
Score:  0.617
Data Source:  BioPlex,STRINGDB
NUP107
Tbio
Novelty:  0.01994155
p_int:  0.986719872
p_ni:  0.013280128
Score:  0.705
Data Source:  BioPlex,STRINGDB
WDR45
Tbio
Novelty:  0.0148072
p_int:  0.983360113
p_ni:  0.016639606
p_wrong:  2.81e-7
Score:  0.254
Data Source:  BioPlex,STRINGDB
NUP43
Tbio
Novelty:  0.11571309
p_int:  0.978038074
p_ni:  0.021961924
p_wrong:  3e-9
Score:  0.822
Data Source:  BioPlex,STRINGDB
NUP133
Tbio
Novelty:  0.02115225
p_int:  0.974678449
p_ni:  0.02532151
p_wrong:  4.1e-8
Score:  0.817
Data Source:  BioPlex,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
p_int:  0.886767684
p_ni:  0.086734805
p_wrong:  0.026497511
Score:  0.87
Data Source:  BioPlex,STRINGDB
HIST2H2AB
Tbio
Novelty:  0.06772132
p_int:  0.853356107
p_ni:  0.146643872
p_wrong:  2.1e-8
Score:  0.174
Data Source:  BioPlex,STRINGDB
VTA1
Tbio
Novelty:  0.01697854
p_int:  0.830901111
p_ni:  0.169023205
p_wrong:  0.000075684
Score:  0.906
Data Source:  BioPlex,STRINGDB
NUP85
Tbio
Novelty:  0.02350514
p_int:  0.772363218
p_ni:  0.227636782
Score:  0.597
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
79.6
sex hormone-binding globulin measurement
2
1
2
62.1
apolipoprotein A 1 measurement
1
1
1
44.2
interleukin 1 receptor antagonist measurement
1
1
1
24.2
interleukin 18 measurement
1
1
1
24.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
79.6
sex hormone-binding globulin measurement
2
62.1
apolipoprotein A 1 measurement
1
44.2
interleukin 1 receptor antagonist measurement
1
24.2
interleukin 18 measurement
1
24.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spastin
VGNC:381
459133
Macaque
spastin
706264
Mouse
MGI:1858896
50850
Rat
RGD:1308494
362700
Dog
spastin
VGNC:46703
608582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spastin
Macaque
spastin
Mouse
Rat
Dog
spastin
Publication Statistics
PubMed Score 466.71
PubMed score by year
PubTator Score 270.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title