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Tbio
SPANXC
Sperm protein associated with the nucleus on the X chromosome C

Protein Summary
Description
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358993
  • ENSP00000351884
  • ENSG00000198573

Symbol
  • CTp11
  • CT11.3
  • SPANXE
  • SPANX-C
  • SPANX-E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.36   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.36   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ZC3H11A
Tbio
Novelty:  0.49683634
p_int:  0.998530344
p_ni:  0.001469655
p_wrong:  1e-9
Data Source:  BioPlex
GTF2F1
Tbio
Novelty:  0.02118098
p_int:  0.972935525
p_ni:  0.027053543
p_wrong:  0.000010932
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.87449479
p_ni:  0.121615385
p_wrong:  0.003889825
Data Source:  BioPlex
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.829600844
p_ni:  0.167753245
p_wrong:  0.002645911
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.814863538
p_ni:  0.175043917
p_wrong:  0.010092545
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.804765231
p_ni:  0.195232095
p_wrong:  0.000002674
Data Source:  BioPlex
CES4A
Tbio
Family:  Enzyme
Novelty:  0.14525977
Score:  0.748
Data Source:  STRINGDB
CES5A
Tbio
Family:  Enzyme
Novelty:  0.01165906
Score:  0.717
Data Source:  STRINGDB
CES2
Tchem
Family:  Enzyme
Novelty:  0.00177726
Score:  0.712
Data Source:  STRINGDB
GAGE2A
Tdark
Novelty:  0.17251368
Score:  0.648
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPANX A/D member 1
493981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPANX A/D member 1
Publication Statistics
PubMed Score 5.36
PubMed score by year
PubTator Score 12.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title