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Tbio
SPANXB1
Sperm protein associated with the nucleus on the X chromosome B1

Protein Summary
Description
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000449283
  • ENSP00000405202
  • ENSG00000227234

Symbol
  • SPANXB
  • SPANXB2
  • SPANXF1
  • B1
  • CT11.2
  • SPANXB
  • SPANX-B
  • SPANXB2
  • SPANXF1
  • SPANXF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.43
tissue sample
0.4
biological term
0.38
phenotype
0.38
small molecule perturbation
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.02   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.02   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
SPANXD
Tdark
Novelty:  0.22064161
p_int:  0.999999908
p_wrong:  9.1e-8
Data Source:  BioPlex
PAPSS2
Tbio
Family:  Enzyme
Novelty:  0.01538798
p_int:  0.99987747
p_ni:  0.00012253
Data Source:  BioPlex
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
p_int:  0.997034414
p_ni:  0.002963353
p_wrong:  0.000002233
Data Source:  BioPlex
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.994744414
p_ni:  0.005255584
p_wrong:  2e-9
Data Source:  BioPlex
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.990513625
p_ni:  0.009486375
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.984762274
p_ni:  0.015237726
Data Source:  BioPlex
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.975981556
p_ni:  0.024018444
Data Source:  BioPlex
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
p_int:  0.970594713
p_ni:  0.029272684
p_wrong:  0.000132603
Data Source:  BioPlex
BPGM
Tbio
Family:  Enzyme
Novelty:  0.03437401
p_int:  0.919203005
p_ni:  0.053354269
p_wrong:  0.027442726
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.817767273
p_ni:  0.182232727
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 6.02
PubMed score by year
PubTator Score 19.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title