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Tbio
SPAM1
Hyaluronidase PH-20

Protein Summary
Description
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223028
  • ENSP00000223028
  • ENSG00000106304
  • ENST00000340011
  • ENSP00000345849
  • ENST00000402183
  • ENSP00000386028
  • ENST00000439500
  • ENSP00000402123
  • ENST00000460182
  • ENSP00000417934

Symbol
  • HYAL3
  • PH20
  • HYA1
  • PH20
  • HYAL1
  • HYAL3
  • HYAL5
  • PH-20
  • SPAG15
  • HEL-S-96n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.6
gene perturbation
0.59
protein domain
0.58
cell type or tissue
0.45
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.33   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.33   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.933
Data Source:  STRINGDB
IDUA
Tbio
Family:  Enzyme
Novelty:  0.00288117
Score:  0.92
Data Source:  STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
Score:  0.915
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.904
Data Source:  STRINGDB
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
Score:  0.904
Data Source:  STRINGDB
HAS2
Tbio
Family:  Enzyme
Novelty:  0.0025539
Score:  0.772
Data Source:  STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
Score:  0.751
Data Source:  STRINGDB
MST1R
Tchem
Family:  Kinase
Novelty:  0.002318
Score:  0.74
Data Source:  STRINGDB
HMMR
Tchem
Novelty:  0.0039196
Score:  0.644
Data Source:  STRINGDB
ADAM2
Tbio
Family:  Enzyme
Novelty:  0.00586482
Score:  0.639
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Fertilization (R-HSA-1187000)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Interaction With Cumulus Cells And The Zona Pellucida
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Fertilization
Interaction With Cumulus Cells And The Zona Pellucida
Reproduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reaction time measurement
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reaction time measurement
1
0.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm adhesion molecule 1
VGNC:8763
472498
Macaque
sperm adhesion molecule 1
696249
Mouse
MGI:1921718
74468
Rat
RGD:1566275
500052
Dog
sperm adhesion molecule 1
VGNC:46700
475211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm adhesion molecule 1
Macaque
sperm adhesion molecule 1
Mouse
Rat
Dog
sperm adhesion molecule 1
Publication Statistics
PubMed Score 265.33
PubMed score by year
PubTator Score 86.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title