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Tbio
SPAG9
C-Jun-amino-terminal kinase-interacting protein 4

Protein Summary
Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction. This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262013
  • ENSP00000262013
  • ENSG00000008294
  • ENST00000357122
  • ENSP00000349636
  • ENST00000505279
  • ENSP00000426900
  • ENST00000510283
  • ENSP00000423165

Symbol
  • HSS
  • KIAA0516
  • MAPK8IP4
  • SYD1
  • JLP
  • CT89
  • HLC4
  • HLC6
  • JIP4
  • PHET
  • PIG6
  • HLC-6
  • JIP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
virus perturbation
0.94
transcription factor perturbation
0.91
hub protein
0.9
biological process
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.47   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.47   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
SMCO1
Tdark
Novelty:  0.56580218
p_int:  0.999982808
p_ni:  0.000017192
Score:  0.686
Data Source:  BioPlex,STRINGDB
C16orf45
Tbio
Novelty:  0.00913059
p_int:  0.998733297
p_ni:  0.001266703
Data Source:  BioPlex
MAPK8IP3
Tbio
Family:  Enzyme
Novelty:  0.01127812
p_int:  0.998462761
p_ni:  0.001537239
Score:  0.559
Data Source:  BioPlex,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.998365317
p_ni:  0.001634683
Score:  0.49
Data Source:  BioPlex,STRINGDB
MREG
Tbio
Novelty:  0.02056739
p_int:  0.9964243
p_ni:  0.0035757
Score:  0.538
Data Source:  BioPlex,STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.995892068
p_ni:  0.004107932
Data Source:  BioPlex
RCCD1
Tbio
Novelty:  0.07481641
p_int:  0.994910894
p_ni:  0.005089106
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.981811365
p_ni:  0.018188635
Data Source:  BioPlex
FAM219B
Tdark
Novelty:  5.26378794
p_int:  0.969140346
p_ni:  0.030859654
Score:  0.241
Data Source:  BioPlex,STRINGDB
ZBED1
Tbio
Family:  TF
Novelty:  0.01645222
p_int:  0.967726712
p_ni:  0.032273288
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
63.9
body height
1
1
1
17.8
BMI-adjusted hip circumference
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
63.9
body height
1
17.8
BMI-adjusted hip circumference
1
4.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 9
VGNC:9646
455131
Macaque
sperm associated antigen 9
707613
Mouse
MGI:1918084
70834
Rat
RGD:1311289
360600
Dog
sperm associated antigen 9
VGNC:46699
480557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 9
Macaque
sperm associated antigen 9
Mouse
Rat
Dog
sperm associated antigen 9
Publication Statistics
PubMed Score 175.47
PubMed score by year
PubTator Score 112.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title