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Tbio
SPAG9
C-Jun-amino-terminal kinase-interacting protein 4

Protein Summary
Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction. This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262013
  • ENSP00000262013
  • ENSG00000008294
  • ENST00000357122
  • ENSP00000349636
  • ENST00000505279
  • ENSP00000426900
  • ENST00000510283
  • ENSP00000423165

Symbol
  • HSS
  • KIAA0516
  • MAPK8IP4
  • SYD1
  • JLP
  • CT89
  • HLC4
  • HLC6
  • JIP4
  • PHET
  • PIG6
  • HLC-6
  • JIP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
virus perturbation
0.94
transcription factor perturbation
0.91
hub protein
0.9
biological process
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.37   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.37   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0